In plants, imprinted gene expression occurs in endosperm seed tissue and is sometimes associated with differential DNA methylation between maternal and paternal alleles(1). Imprinting is theorized to have been selected for because of conflict between parental genomes in offspring(2), but most studies ...
Cis genetic or trans genetic or epigenetic variation is associated with imprinting variation [20]. The traits controlled by imprinted genes reflect the genotype of a single parent. To date, although functional studies of imprinting genes are limited, the important role of imprinting genes has been ...
The G protein Gsα is imprinted in a tissue-specific manner, being primarily expressed from the maternal allele in some tissues, such as renal proximal tubules. The Gsα promoter is unmethylated, but is downstream of a differentially methylated region [the exon 1A differentially methylated region ...
Parent-of-origin–dependent expression of imprinted genes is mostly associated with allele-specific DNA methylation of the CpG islands (CGIs) called germ line differentially methylated regions (gDMRs). Although the essential role of gDMRs for genomic imprinting has been well established, little is ...
DNA methylation at gene promoters is generally associated with transcriptional silencing. Somatic DMRs Also known as secondary differentially methylated regions (DMRs), somatic DMRs are regions of the genome containing allele-specific DNA methylation that is established after fertilization. Primordial germ ...
Imprinting is associated with increased capacity for neurotransmitter release (see above and also this section). Therefore we inquired whether the levels of clathrin heavy and light chains in the IMM change in a learning-related manner 10 and 25 h after the start of a 1-h training period. At...
摘要: Methyltransferase-deficient mice reveal that DNA methylation is required for the somatic-cell maintenance of parental imprinting, which alters the expression of a gene according to the parent from which it was inherited.关键词: mamiferos, mammifere, DNA METHYLATION, mammals, GENOMIC IMPRINTING,...
436. Investigation of the role of SRC in capacitation associated tyrosine phosphorylation of human spermatozoa Capacitation is a pre-requisite for mammalian spermatozoa allowing them to gain the ability to fertilise an oocyte. A fundamental part of this mechanism is... L.,A.,Mitchell,... - 《...
The mechanisms involved in chromosomal imprinting, or labeling of DNA, is associated with methylation of DNA in many organisms. Imprinting is a reversible, differential marking of genes or chromosomes that is determined by the sex of the... B Gabrys,JL Capinera,JC Legaspi,... - Springer Nether...
population suggest that increasing hyperglycemia in pregnancy is associated with an increased risk of childhood obesity. More research is needed to determine whether treatment of GDM may be a modifiable risk factor for childhood obesity. 展开