we wondered whether we could construct the convergent variants in advance and investigate to what extent they will evade the humoral immune response. To do this, we must first evaluate the antibody evasion mechanism and
In fact, mRNA-vaccinated individuals displayed an even higher propor- tion of cross-reactive memory B cells, probably because the overall humoral immune response induced by mRNA vaccines is stronger than that induced by inactivated vaccines45. In addition, recent studies on mRNA-vaccinated individuals...
On the other hand, our study shows that the initially higher specific antibody titers due to former imprinting via vaccination or prior infection significantly increased the humoral immune response, and therefore outperformed the humoral immune response of nave study participants....
In fact, mRNA-vaccinated individuals displayed an even higher propor- tion of cross-reactive memory B cells, probably because the overall humoral immune response induced by mRNA vaccines is stronger than that induced by inactivated vaccines45. In addition, recent studies on mRNA-vaccinated individuals...