The functional domain consisting of α -helices and β -strands may be critical for the ligand binding activity of this class of proteins. HaSCP-2 exhibited a hydrophobic channel consisting of five α -helices lying on one side of a plane expanded by stranded β -sheets. The ...
X-ray crystal structures and other biochemical and biophysical studies of some of the moonlighting proteins have added to our understanding of how one protein can perform two different functions and, in some cases, provided information about the triggers and molecular mechanisms involved in switching ...
The genusBacteroidescontains Gram-negative, nonsporeforming, nonmotile, anaerobic rods generally isolated from the gastrointestinal tract (GI-tract) of humans and animals. Up until about 12 years ago the genus was quite diverse and included nearly every organism that fit this generalized description. ...
At enrolment, participants provided information on a wide range of factors, physical measurements were taken, and biological samples (blood, urine and saliva) were collected for long-term storage. Participants have now been followed up for over a decade with more than 52,000 incident cancer cases...
they continue. �He is the guy we always turn to for information on how to make our menus better�, says another chef in the kitchen. He has perfectly melded the exotics of Caribbean ingredients with the healthy tenets of Spa Cuisine. This is why six of ...
However, indirect tests allow to get only preliminary (often little reliable) information regarding biocompatibility of the implants. There are also tremendous difficulties faced by scientists willing to use in vitro cellular models for the evaluation of biocompatibility of bioceramic- or/and polymer-...
[24,64]. In addition, current gene editing techniques, such as CRISPR/Cas9, have made it possible to efficiently and economically target the zebrafish genome to produce mutants based on information from clinical screening for scoliosis. Reverse screening for scoliosis mutants can also help to ...
oncophora. Analysis of transcriptome data and their comparison with genomic data is well known to provide useful information about an organism [5–7]. This approach has led to studies on identifying new drug targets (e.g. [8–10]), understanding nematode biology [11], and detecting parasite...
included 188 LTS and 178 STS subjects with the known survival status in our analysis. We focused our analysis on expression data of 118 proteins extracted from reverse phase protein arrays (RPPAs)—a highly sensitive, reproducible, and high-throughput proteomic method for protein expression ...
Messenger RNA expression of prooxidative genes (NOX1, NOX2, NOX4), antioxidative genes (SOD1, SOD2, SOD3, GPx1, HO-1, Catalase) and of genes coding for intracellular regulatory proteins involved in aging (SIRT1, SIRT6, FOXO1) in aged wild-type and M1R−/− mice. Expression of ...