Important Dates, Events, and Milestones in Alaska History Offers a chronological timeline of important dates, events, and milestones in Alaska history Alaska's modern history is very short; it was not discovered by the developed world until halfway through the 18th century. However, the ...
Med. 373, 1627–1639 (2015). References 144 and 145 are responsible for the approval of the PD1 antibody nivolumab. Article CAS PubMed PubMed Central Google Scholar Vokes, E. E. et al. Nivolumab versus docetaxel in previously treated advanced non-small-cell lung cancer (CheckMate 017 and...
Aim: To determine whether gender-specific responses to perinatal and neonatal events and exposures explain the male disadvantage in early childhood outcom... SR Hintz,DE Kendrick,BR Vohr,... - 《Acta Paediatrica》 被引量: 297发表: 2010年 Factors predictive of follow-up clinic attendance and ...
The occurrence of genome damaging events such as double-strand breakage can disrupt the association of PTTG1 with Ku-70 [50]. These findings were supported by Zhou et al. [51], who showed that human cells treated with DNA-damaging drugs doxorubicin and bleomycin activated p53 and suppressed ...
Ab-induced increases in caspase-3 activation and the production of caspase-3-truncated tau species in neurons were reduced when the astrocytic response was attenuated with minocycline. Taken together, these results show that astrocytes are important mediators of the neurotoxic events downstream of ...
Concern about calcium supplementation causing cardiovascular events can widen the gap between calcium intakes and calcium recommendations. At this time, the association between calcium intake and cardiovascular disease is inconsistent, lacks a plausible mechanism, has no dose–response effect, and is not ...
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Figure S3A). In order to sort out biological relevant patterns within the complexity caused by the modular structure of plasmids and the propensity of inter-plasmid recombination events, we defined the plasmid content in the four STs by presence ofrepgenes encoding replication initiator proteins and...
TP53 mutations are extremely rare events in MPM, but the P53 protein can be inactivated by several other molecular mechanisms (Papp et al, 2001a,b; Toyooka et al, 2008). One of these putative mechanisms is an amplification and/or overexpression of MDM2, which exerts an E3 ubiquitin protein...
This finding indicated that independent duplication events, except whole genome duplication, occurred. Fig. 7 Microsynteny of WRKY Group III TFs in tomato, Arabidopsis, and rice. a Microsynteny of WRKY TFs across tomato and Arabidopsis. Tomato chromosomes label Sl01- Sl12. AT01-AT05 represents ...