W1550 Importance of Membrane Cholesterol for Cell Integrity: Detrimental Effects of LovastatinW1550 Importance of Membrane Cholesterol for Cell Integrity: Detrimental Effects of Lovastatin - Gastroenterologydoi:10.1016/S0016-5085(09)63175-9Zhou, Yong...
Structural basis for cholesterol transport-like activity of the hedgehog receptor patched. Cell 175, 1352–1364.e14 (2018). Article CAS PubMed PubMed Central Google Scholar Qian, H. et al. Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm. Nat. Commun. 10, ...
Article: The importance of cholesterol in maintenance of P-glycoprotein activity and its membrane perturbing influence
It protects the cell and controls the materials entering and exiting it. It surrounds the cytoplasm and is located in the outermost layer of the cell. Location of cell membrane in the cells The cell membrane comprises lipids (glycerophospholipids and cholesterol), proteins, and carbohydrates. The ...
(2) ESCRT independent pathway: Budding is mainly mediated by a modified lipid composition of the vesicle membrane, with ceramides, cardiolipids, or cholesterol. Flotillins and Rab31 help to internalize tyrosine kinase receptors besides acting as scaffold proteins and preventing lysosomal degradation, re...
Moreover, pollenkitt is involved in pollen stickiness, which enables adhesion to insect bodies and pollen packaging by bees (i.e., pollen transport)22. As in many plants, the pollen of Echium vulgare, L. salicaria, O. luteus and Reseda lutea show high levels of 24-methylenecholesterol, ...
Cholesterol synthesis occurs via mevalonate pathway, and it requires large amounts of energy [14,15]. The newly synthesized cholesterol is transported to its destination, mainly to the plasma membrane, but also in a smaller extent to other cellular membranes [9]. 3-hydroxy-3-methylglutaryl coenzy...
These fruits are low in saturated fats and cholesterol, making them ideal for those battling obesity. Their low caloric content and a low glycemic index (GI) equal to 44 cause a slow and slight increase in blood sugar levels after consumption, which makes apples a recommended choice for ...
Cholesterol is mostly transported in the blood in the form of low-density lipoproteins (LDL) bound to protein. When in need, the cell synthesizes receptor proteins specific to LDL and attaches them to the cell membrane, where they associate with clathrin-coated pits. LDL bind to these ...
Lipid-protein interactions stabilize protein oligomers, shape their structure, and modulate their function. Whereas in vitro experiments already account for the functional importance of lipids by using natural lipid extracts, in silico methods lack behin