Preventable ADRs accounted for approximately 19.9% of the cost increase among all ADR cases. The regression analysis revealed that 'ADR-related hospitalization' was a significant (p < 0.05) factor leading to an increase in the direct medical costs. Conclusion Drug-related ED visits increase the ...
Incidence, Preventability, and Impact of Adverse Drug Events (ADEs) and Potential ADEs in Hospitalized Children in New Zealand Background: Adverse drug events (ADEs) are an important problem in all hospitalized patients as these events represent medication-related patient harm. Few... Dr,Desireé,...
There is suggestive evidence that higher doses of paroxetine than those used in major depression are needed for benefit in OCD. Because of their safety and beneficial adverse-event profile, the SSRIs have become the leading choice in the pharmacological management of OCD. 展开 ...
most commonly in one of the four FGFR receptor tyrosine kinase genes, can potentially be targeted with broad-spectrum multi-kinase or FGFR selective inhibitors. The complete spectrum of these mutations in paediatric cancers is emerging as precision medicine programs perform comprehensive sequencing of in...
Overall, major bleeding at 1 year and at long-term follow-up was associated with an increased risk of MACE, cardiac death and ST. Patients who had any bleeding event were more likely to prematurely discontinue antiplatelet therapy (50% vs. 9.6%, P < 0.001). Conclusions: In DES-treated ...
It finds that abortive coups, rather than successful coups, had the greatest adverse impact on economic growth over the 1960–1986 period. Coup plots were also observed to be growth-inhibiting. This deleterious "direct" effect of PI is observed to be channeled via the deterioration in the ...
MFC can also be used to detect expression of leukemia stem cell (LSC) markers, including CLL1, CD123, CD200, and others [30,31,32,33], and some studies suggest that detection of LSCs within MRD is an adverse prognostic factor [31, 34, 35]. While antibody panels are increasingly ...
To deny this is to deny a fundamental property of risk; these are percentages, estimated as long-run frequencies of the event of interest in relevant patient populations. These are factual statements based on empirical observations and as such are the only objective estimates of risk that can ...
of regional conflict – could also lead to sharp tightening in global credit conditions or commodity price shock, flight to safety, and a collapse in business and consumer confidence. High debt burdens would limit governments and central banks’ ability to support businesses in the event of...
(such as producing the aberrant shorter transcript isomers in spermatocytes). They found that ALKBH5-dependent m6A demethylation regulates the correct splicing of long 3′UTR transcripts. METTL3 typically mediates the m6A modification of an intron at the 5'-splicing site, which enhances its ...