Micro- and nanoplastics can interact with various biologically active compounds forming aggregates of which the effects have yet to be understood. To this end, it is vital to characterize these aggregates of key compounds and micro- and nanoplastics. In
As all the effects of IFNs are mediated through ISGs, understanding of the function of these genes might lead to more efficacious antiviral and anti-cancer drugs. Abstract The family of interferon (IFN) proteins has now more than reached the potential envisioned by early discovering virologists:...
Chronic stress is a major risk factor for several human disorders that affect modern societies. The brain is a key target of chronic stress. In fact, there is growing evidence indicating that exposure to stress affects learning and memory, decision makin
Alcohol, nicotine, and cannabis are among the most commonly used drugs. A prolonged and combined use of these substances can alter normal brain wiring in different ways depending on the consumed cocktail mixture. Brain connectivity alterations and their
“This research identifies the regions of the brain which are important,” said Mackay, the Self Family Endowed Chair in Human Genetics. “Now, we can see what genes are expressed when exposed to cocaine and whether there are Federal Drug Administration-approved drugs that could...
I moved to the Bay Area from Southern California, where I lived in the predominantly Black and Latina/o/x, very low-income city of San Bernardino. Unemployment, drugs, violence — all of that was prevalent in my life. I didn’t have an opportunity to visit the University of California,...
The most frequent concerns were on the possibility of infection from visiting the hospital for routine visits or the emergency department for prolonged or subsequent seizures (Table 2). Another frequent concern was on supply of drugs; however, only 12.6% of responders reported difficulties in obtaini...
Drugs on admission, n (%) Beta-blocker 31 (47.7) 99 (32.4) 0.019 ACE inhibitor 35 (54.7) 86 (28.1) <0.001 Angiotensin receptor blocker 14 (21.5) 42 (13.7) 0.110 Calcium channel blocker 24 (36.9) 50 (16.3) <0.001 Diuretics 31 (47.7) 69 (22.6) <0.001 a2 Agonist 5 (7.7) 9 (...
Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-survival and pro-death pathways in malignant, stromal, endothelial and immune cells, hence causing a profound cellular and biological reconfiguration via multiple
The Cognitive Reserve (CR) theory posits that brains with higher reserve can cope with more cerebral damage to minimize clinical manifestations. The aim of this study was to examine the effect of education (CR proxy) on brain structure and function in Alzheimer’s disease (AD) and amnestic mil...