Chronic stress is a major risk factor for several human disorders that affect modern societies. The brain is a key target of chronic stress. In fact, there is growing evidence indicating that exposure to stress affects learning and memory, decision makin
Neurobiology of the adolescent brain and behavior: implications for substance use disorders. Adolescence is a developmental period that entails substantial changes in risk-taking behavior and experimentation with alcohol and drugs. Understanding ho... BJ Casey,RM Jones - 《J Am Acad Child Adolesc Psyc...
Yes Julie. Who on earth would ignore the adverse effects that are already out there for effects of certain groups of drugs and surgeries on females to progress a narrative that seems to benefit on sex class over another? Will any acknowledgement of these health risks to females be forth comin...
mortality impact and cost-effectiveness of cancer drugs: It analyzes the correlation across 36 countries between the relative mortality from 19 types of cancer in 2015 and the relative number of drugs previously launched in that country to treat that type of cancer, controlling for relative ...
As all the effects of IFNs are mediated through ISGs, understanding of the function of these genes might lead to more efficacious antiviral and anti-cancer drugs. Abstract The family of interferon (IFN) proteins has now more than reached the potential envisioned by early discovering virologists:...
PreEP [pre-exposure prophylaxis] if they're in a situation where their risk of contracting HIV is heightened," says Ryan. "Just as we want to understand the cognitive impacts of HIV, we also want to see whether these drugs alone are impacting the brain health of otherwise healthy people....
“This research identifies the regions of the brain which are important,” said Mackay, the Self Family Endowed Chair in Human Genetics. “Now, we can see what genes are expressed when exposed to cocaine and whether there are Federal Drug Administration-approved drugs that could ...
while patenting has increased over time, so too has the fraction of drugs subject to patent challenges and the speed with which they are challenged [71]. A drug with weaker patents and higher drug sales is more likely to face generic challenge. Weaker patents are less likely to be related ...
Fasting is known to influence learning and memory in mice and alter the neural networks that subserve these cognitive functions. We used high-resolution functional MRI to study the impact of fasting on resting-state functional connectivity in mice follow
Testing co-medication approaches of increased concentrations of lithium with antiepileptic drugs in humans is not feasible. Therefore, a preclinical human model system with lithium-induced abnormal neuronal activity, that is allowing the evaluation of the efficacy of drugs in counteracting pathophysiological...