Micro- and nanoplastics can interact with various biologically active compounds forming aggregates of which the effects have yet to be understood. To this end, it is vital to characterize these aggregates of key compounds and micro- and nanoplastics. In
However, as already mentioned, the effects of exposure to a risk environment may not be seen in basal levels but appear when the individual encounters challenge later in life such as stress, trauma, or risk consumption of drugs of abuse. DYN, for example, have been ...
As all the effects of IFNs are mediated through ISGs, understanding of the function of these genes might lead to more efficacious antiviral and anti-cancer drugs. Abstract The family of interferon (IFN) proteins has now more than reached the potential envisioned by early discovering virologists:...
Chronic stress is a major risk factor for several human disorders that affect modern societies. The brain is a key target of chronic stress. In fact, there is growing evidence indicating that exposure to stress affects learning and memory, decision makin
The Cognitive Reserve (CR) theory posits that brains with higher reserve can cope with more cerebral damage to minimize clinical manifestations. The aim of this study was to examine the effect of education (CR proxy) on brain structure and function in Alzheimer’s disease (AD) and amnestic mil...
“This research identifies the regions of the brain which are important,” said Mackay, the Self Family Endowed Chair in Human Genetics. “Now, we can see what genes are expressed when exposed to cocaine and whether there are Federal Drug Administration-approved drugs that could...
Transmission intensity also affects genetic signals of resistance through its effect on the types of drugs used and how they are deployed. High transmission results in intermittent and reduced drug pressure, and the effect on selective sweeps depends on the tradeoff between parasite fitness in the pr...
Hemphill and Sampat also found that while patenting has increased over time, so too has the fraction of drugs subject to patent challenges and the speed with which they are challenged [71]. A drug with weaker patents and higher drug sales is more likely to face generic challenge. Weaker ...
Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-survival and pro-death pathways in malignant, stromal, endothelial and immune cells, hence causing a profound cellular and biological reconfiguration via multiple
Alcohol, nicotine, and cannabis are among the most commonly used drugs. A prolonged and combined use of these substances can alter normal brain wiring in different ways depending on the consumed cocktail mixture. Brain connectivity alterations and their