The impact of genetic variation on overall disease burden has not been comprehensively evaluated. We introduce an approach to estimate the effect of genetic risk factors on disability-adjusted life years (DALYs; ‘lost healthy life years’). We use genetic information from 735,748 individuals and ...
Rank Abbreviated Journal Title Total Cites Impact Factor Immediacy Index Number of Articles Published Cited half-life 1 Nature Genetics 54053 24.176 7.144 202 6.1 2 Nature Rev Genetics 9196 22.947 4.593 81 3.6 3 Annual Rev Genetics 4803 19.098 0.421 19 7.1 4 Genes & Development 48407 10.050 ...
In an attempt to provide some explanation for the observed differences in pain perception and analgesic requirements during labor and delivery between women, the idea that genetic variability is an important factor has emerged over the past decade. Bearing in mind the challenges posed when evaluating...
Top 10 genes identified by Regulatory Impact Factor 2 (RIF2) score by contrasting high minus low IMF groups.Aline S. M. CesarLuciana C. A. RegitanoJames E. KoltesEric R. FritzWatersDante P. D. LannaGustavo GasparinGerson B. Mourão...
Each factor increases the risk for developing the disease compared with the general population.5 The ACP also encourages doctors to discuss the risks and benefits of genetic testing with their patients. This should in- clude a discussion of the available treatment and its efficacy, as Genetics IN...
GU 5′ ss in a dose-dependent manner but no effect on canonical AG|GU 5′ss or other noncanonical splice sites (Fig.3band Supplementary Fig.7). For example,MYB, a transcription factor protooncogene targeted by a number of antitumor therapies, contains a risdiplam-induced exon (Fig.3c)....
A data aggregation strategy to model specific transcriptional processes based on transcription factor and cell-state specificity. Publication in American Journal of Human Genetics: IMPACT: Genomic Annotation of Cell-State-Specific Regulatory Elements Inferred from the Epigenome of Bound Transcription Factors ...
作者: N Rezaei-Ghaleh,F Azizi 摘要: Background: The journal impact factor is increasingly employed to evaluate the quality of 关键词: biomedical research Iranian universities journal impact factor quality assessment subject normalization DOI: 07102/AIM.0011 被引量: 35 年份: 2007 收藏...
The fact that sperm carry more than the paternal DNA has only been discovered just over a decade ago. With this discovery, the idea that the paternal condition may have direct implications for the fitness of the offspring had to be revisited. While this
et al. Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature 459, 569–573 (2009). CAS PubMed PubMed Central Google Scholar Yuan, Q. et al. Regulation of brain-derived neurotrophic factor exocytosis and gamma-aminobutyric acidergic interneuron synapse by the ...