Overall, we estimated the HRs through 92,560 survival analyses: associations of 1,044 common variants, 9 rare variant gene burdens, 74 HLA alleles and 30 PGSs with 80 diseases. After shrinkage, we retained 3,123 HRs for genetic exposure–disease pairs, most of which (67.1%) were genome-wi...
Objective To study the impact of gender factor on the candidate gene study of essential hypertension (EH). Methods The polymerase chain reaction (PCR) was performed to analyze the ACE gene I/D polymorphism of hypertensive patients (50 men and 50 women) and normal controls (50 men and 50 wom...
Impact Factor Immediacy Index Number of Articles Published Cited half-life 49 Crit Rev Eukar Gene 680 3.342 0.294 17 6.7 50 Evol Dev 1080 3.293 1.120 50 3.6 Table 2: Excerpt from Thomson Scientific 2006 JCR Science Editor Journal Summary List, Genetics & Heredity category (131 journals), ...
We hereafter focus on the effect of sex on gene expression as it potentially represents a major factor underlying leg exaggeration through differences in allometric coefficients [41] (Additional file 3: Figure S2). Leg exaggeration and sex-biased gene expression...
GU 5′ ss in a dose-dependent manner but no effect on canonical AG|GU 5′ss or other noncanonical splice sites (Fig.3band Supplementary Fig.7). For example,MYB, a transcription factor protooncogene targeted by a number of antitumor therapies, contains a risdiplam-induced exon (Fig.3c)....
Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution We recently described an association between risk of type 2diabetes and variants in the transcription factor 7-like 2 gene (TCF7L2; formerly TCF4), with a ... A Helgason,S Pálsson,G Thorleifsson,......
et al. Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis. Nature Genet. 41, 211–215 (2009). Article CAS PubMed Google Scholar Fanciulli, M. et al. FCGR3B copy number variation is associated with susceptibility to systemic, but not ...
Research Impact Score*: 0.8 Impact Factor: 2 SCIMAGO SJR: 0.501 SCIMAGO H-index: 59 Research Ranking (Genetics) 98 Research Ranking (Genetics and Molecular Biology) 336 Number of Best scientists*: 7 Documents by best scientists*: 8 Journal...
The hypotheses outlined above for the evolution of genetic imprinting and the role of RNAs as signals among different units may apply to any epigenetic factor transmitted via sperm. Males can undoubtedly benefit from transmitting more than just a genome in their gametes, and the idea that these ...
The CommonMind Consortium sequenced RNA from dorsolateral prefrontal cortex of people with schizophrenia (N = 258) and control subjects (N = 279), creating a resource of gene expression and its genetic regulation. Using this resource, ∼20% of schizophrenia loci have variants that could ...