Cell death mediated by genetically defined signaling pathways influences the health and dynamics of all tissues, however the tissue specificity of cell death pathways and the relationships between these pathways and human disease are not well understood. We analyzed the express...
Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-survival and pro-death pathways in malignant, stromal, endothelial and immune cells, hence causing a profound cellular and biological reconfiguration via multiple
leading to recruitment of guanine nucleotide exchange factor (GEF) by Src homology 2 domain containing transforming protein (SHC) and growth factor receptor-bound protein 2 (GRB2), which substitutes GDP with GTP to activate RAS. Once in its active state, or in the case ...
Hyperactive coagulation might cause dangerous complications such as portal vein thrombosis and pulmonary embolism after mesenchymal stem/stromal cell (MSC) therapy. Tissue factor (TF), an initiator of the extrinsic coagulation pathway, has been suggested as a predictor of this process. Methods The expr...
9 HIGM was diagnosed by mutation analysis of CD40 ligand (CD50L), CD40, and activation-induced cytidine deaminase genes in the patients with reduced serum levels of IgG and IgA and normal or elevated IgM level.21 Mutations in the tumor necrosis factor receptor family member Transmembrane ...
An adequate treatment selection, both in bacterial14, 15, 16 and in A/H1N1(+) pneumonia,17, 18 is key because it has been proved to be an important protective factor against mortality. In fact, the importance of initiating early empiric treatment in order to improve prognosis is an ...
Journal of Cancer Research PubMed indexed journals, Impact Factor journals, Web of Science indexed journals, Medline indexed journals
Journal Impact Factor: 2.18* Cellular & Molecular Medicine: Open accessis a peer reviewed, open access journal that encompasses all fundamental and molecular aspects of Medicine. The Journal publishes current and comprehensive reviews, original research articles, short communications/letters, drug clinical...
The impact of genetic variation on overall disease burden has not been comprehensively evaluated. We introduce an approach to estimate the effect of genetic risk factors on disability-adjusted life years (DALYs; ‘lost healthy life years’). We use genet
Lung cancer is the leading cause of cancer-associated mortality worldwide1. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx s