According to the Department of Health and Human Services, obesity is a significant public health issue affecting roughly 40% of women of reproductive age [1]. Maternal obesity is a modifiable risk factor known to contribute to adverse pregnancy outcomes. It carries substantial short-term and long-...
Impact of DNA methyltransferases on the epigenetic regulation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor expression in malignant melanoma. Biochem. Biophys. Res. Commun. 441, 743-750, doi: 10.1016/j. bbrc.2013.10.114 (2013)....
Chiarella E, Aloisio A, Scicchitano S et al (2021b) Regulatory role of microRNAs targeting the transcription co-factor ZNF521 in normal tissues and cancers. Int J Mol Sci 22.https://doi.org/10.3390/IJMS22168461 Chiarella E, Nisticò C, Di Vito A et al (2022) Targeting of mevalonate-is...
13,14 The tissue abnormalities of these autophagy-defective mice are often accompanied by the accumulation of p62 and ubiquitinated proteins. In the liver, p62 sequesters the E3 ligase KEAP1 and stabilizes the antioxidant transcription factor NRF2/NFE2L2.15 The deletion of p62 or NRF2 abolishes ...
Culture is an important factor that warrants further investigation. Culture influences worldviews, language, and health-seeking behaviors and serves as a critical foundation for influencing practice and research. Research suggests that cultures that value the collective benefits of vaccinations report a high...
Specifically, eight a priori hypotheses concerning factor-outcome relations were formulated: 1. Middle cerebral artery occlusion duration affects (A) infarct size variability and (B) mortality. 2. Type of focal cerebral ischemia procedure affects (A) infarct size variability and (B) mortality. 3. ...
This drop in glutathione was concomitant in Nuclear Factor Erythroid 2-related factor 2 (NRF2) induction in HaCaT but not in HCT116 cells (Fig. S1B). NRF2 controls several different antioxidant pathways26. The first one is glutathione (GSH) production and regeneration, suggesting that cancer ...
We found a significant correlation between CRIP1 and HER2 (human epidermal growth factor receptor 2) expression levels (p = 0.016) in tumor tissues. In Kaplan Meier analyses, CRIP1 expression was significantly associated with the distant metastases-free survival of patients, revealing a better...
Three N-terminal serine phosphorylation sites (S104, S106, S118) in ERα were shown to be necessary, but not sufficient for growth factor potentiation of ligand-dependent activation and ligand-independent activation of the ERα [5, 23–25]. Of significance from these studies was the ...
Furthermore, the TH1/TH2 balance is affected by zinc. During zinc deficiency, the production of TH1 cytokines, in particular IFN-γ, IL-2, and tumor necrosis factor (TNF)-α is reduced, whereas the levels of the TH2 cytokines IL-4, IL-6, and IL-10 were not affected in cell culture...