Genetic model of childhood absence epilepsyGAERSGlutamate is the putative neurotransmitter of several clinically important pathways, including cortical association fibers, corticofugal pathways such as the pyramidal tract, and hippocampal, cerebellar, and spinal cord pathways. The excitatory actions of ...
Alzheimer’s disease (AD) is a devastating neurodegenerative disease that affects more than 30 million people worldwide. Despite growing knowledge of
Parkinson's disease Recently Published Papers The unanticipated contribution of Zap70 in retinal degeneration: implications for microglial inflammatory activation. 20 Dec 2024 Progress in neurobiology Cyto-, gene, and multireceptor architecture of the early postnatal mouse hippocampal complex. ...
Adversity can manifest in various forms including psychosocial factors such as childhood maltreatment, peer victimisation, social isolation, affective loss, domestic conflict, or poverty, as well as exposure to environmental toxins. Despite the shared aspect of stress biology underlying these adversities, ...
Additionally, cortical thickness reduction was noted in several regions, including the right and left postcentral, superior temporal gyrus and precuneus, which are also affected in Alzheimer’s disease [58, 59]. Although only a subset of these regions remained significant after correction for multiple...
The mammalian gastrointestinal tract is home to trillions of microbes that make up the gut microbiota (GM). These bacteria play many crucial roles in the health and wellbeing of their host, including training the immune system [1,2], defending the body against disease [3,4,5], and contribu...
Neurological disorders are diseases of the brain,spineand the nerves that connect them. There are more than 600 diseases of the nervous system, such asbrain tumors, epilepsy, Parkinson's disease and stroke as well as less familiar ones such as front temporal dementia. It is any disorder of ...
The prevalence of osteoarthritis (OA) is significantly higher in women than in men, and the disease significantly affects both physical and autonomic functions2. Women are particularly susceptible to OA, accounting for approximately 60% of all OA patients3. Age is a major risk factor, with the ...
Intimate partner violence (IPV) has negative spillovers on other family members. In particular, children are at risk in various ways. This chapter treats witnessing IPV as an adverse childhood event that has long-term consequences on the behaviour of the children. Specifically, this chapter examines...
ADNP is a multitasking protein with the function as a transcription factor, playing a critical role in brain development. Furthermore, ADNP variants have been identified as one of the most common single-gene causes of autism spectrum disorder (ASD) and intellectual disability. Methods We assembled...