Transient or persistent immunosuppression is a known risk factor for morbidity and mortality in critically ill patients. Aim of the present study is to eva
et al. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat. Med. 15, 545 (2009). Article CAS PubMed Google Scholar Kleinewietfeld, M. et al. Sodium chloride drives autoimmune disease by the induction of ...
Itaconate can activate the nuclear transcription factor Nrf2 (nuclear factor erythroid-derived 2-like 2) and reduce STING mRNA levels by inducing mRNA instability [222]. In addition to its in vitro relevance, itaconate can suppress STING expression and type I IFN in cells from patients with the...
Biomarker studies with emerging AD treatments targeting other molecules such as IL22-Rα1, tumor necrosis factor receptor superfamily member 4 (i.e., OX40), and specificity protein 1 (i.e., Sp1) may reveal additional AD-related biomarkers. The assessment of AD-related biomarkers will play ...
After cloning, IL-4 was proven to be a potent switch factor to IgE in B cells [75]. The source of IL-4 was initially shown to be Th2 cells [76], and later, other immune cells and inflammatory cells, such as natural killer T cells [77], basophils [78], mast cells [79], ...
A recent genome wide CRISPR screen identified TRAF2 as a key gene sensitising tumour cells to killing by T cell-derived tumour necrosis factor [181]. Consistent with this, TRAF2 loss was found in recent a pan-cancer analysis to be significantly associated with response to CPI therapy [130]...
Previously, we reported that enhancer of polycomb1 (Epc1) induces skeletal muscle differentiation through the serum response factor (SRF). Considering that... H Joung,JS Kwon,JR Kim,... - 《Atherosclerosis》 被引量: 16发表: 2012年 Prevention of vascular smooth muscle cell proliferation and inj...
The primary known factor giving rise to sex differences in early embryogenesis is sex chromosome-linked gene expression (23). In addition to differential expression of X and Y transcripts themselves, differences in autosomal gene expression in early embryonic and extraembryonic tissues have been observed...
EGR1 functions as a new host restriction factor for SARS-CoV-2 to inhibit virus replication through the E3 ubiquitin ligase MARCH8. J. Virol. 97, e0102823 (2023). PubMed Google Scholar Arunachalam, P. S. et al. Systems vaccinology of the BNT162b2 mRNA vaccine in humans. Nature 596,...
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