Metastatic breast cancer (MBC) behaviour differs depending on hormone receptors (HR) and human epidermal growth factor receptor (HER2) statuses. Methods The kinetics of central nervous system (CNS) metastases (CNS metastasis-free survival, CNSM-FS) and subsequent patient’s prognosis (overall surviva...
Thyroid dysfunction, including hyperthyroidism and hypothyroidism, has also been investigated as a risk or preventive factor for human cancers. Yuan et al. reported that thyroid dysfunction might increase the overall cancer incidence and the risk of breast cancer16. Boursi et al. reported that ...
Rebolj, M., Pesola, F., Mathews, C. et al. The impact of catch-up bivalent human papillomavirus vaccination on cervical screening outcomes: an observational study from the English HPV primary screening pilot. Br J Cancer 127, 278–287 (2022). https://doi.org/10.1038/s41416-022-01791-w...
Does antibacterial treatment for urinary tract infection contribute to the risk of breast cancer? Br. J. Cancer, 82 (5) (2000), pp. 1107-1110 View in ScopusGoogle Scholar [22] M.J. Tikkanen, H. Adlercreutz, M.O. Pulkkinen Effects of antibiotics on oestrogen metabolism Br. Med. J., ...
Capsaicin 100 72 Human Methylcholanthrene-induced fibrosarcoma Meth A cells Decreased Fas-associated factor1 (FAF1) expression level Apoptosis [97] Capsaicin 50 36 Human small cell lung cancer H69, DMS 114, DMS 53, and H82 cells Activated TRPV6 and, subsequently, induced calpain-1 and calpain...
An increased expression of Kv10.1 can be triggered by the tumor suppressor p53, as observed in glioblastoma (Bai et al.2013), and the transcription factor E2F1 (Lin et al.2011). Overexpressed Kv10.1 controls cancer cell migration and proliferation by interactions with RAB proteins (Ninkovic et...
Nathan A et al. SELECT: A Phase II Trial of Adjuvant Erlotinib in Patients With Resected Epidermal Growth Factor Receptor–Mutant Non–Small-Cell Lung Cancer. J Clin Oncol. 2019 Jan 10;37(2):97-104. Wen-Zhao Zhong et al. Geftinib versus vino...
BMI: body mass index; HR: hazard ratio; MBC: metastatic breast cancer; CI: confidence interval; HR: hormone receptor; HER2: human epidermal growth factor receptor 2; TNBC: triple negative breast cancer. Declaration of Competing interest V.D reports advisory boards from Roche, Genentech, Lilly,...
Lung cancer is the leading cause of cancer-associated mortality worldwide1. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer prospectively enrolled into the TRACERx s
Understanding how a tumour evolves and avoids immune recognition is paramount to improving cancer immunotherapy and patient outcome. Here we examine our recent integration of multi-region genomic, transcriptomic, epigenomic, pathology, and clinical data,