Davar and Zarour hope to run a larger trial with melanoma patients, as well as evaluating whether FMT may be effective in treating other cancers. Ultimately, their goal is to replace FMT with pills containing a cocktail of the most beneficial microbes for boostingimmunotherapy—but that's still ...
Both studies identified valeric acid and butyric acid as two SCFAs with therapeutic effects in cancer immunotherapy. SCFAs provide energy for immune cells. SCFAs derived from the gut microbiota can regulate glycolysis, the tricarboxylic acid (TCA) cycle, the PPP, and fatty acid oxidation (FAO) of...
DKK1 compositions comprising a DKK1 protein, DKK1 peptide, DKK1 DNA, DKK1-specific CTLs and Th1 cells and associated methods for treating cancer and cancer-mediated disorders in a h
TARGETED ONCOLOGY: Can you discuss the prognosis of patients with anaplastic thyroid cancer? Cabanillas: Up until recently, there were very few options for these patients for systemic therapy. Cytotoxic chemotherapy is not very effective, and so it wasn’t until May 2018 when the FDA app...
When using standard forms of cancer therapies, including pills and infused drugs, doctors can interrupt or lower drug dosing to respond to treatment toxicities. With cell-based immunotherapies, this is not possible after the cells are infused. So UNC Lineberger researchers engineered T-cells to incl...
Although substantial screening and vaccination programs are in effect, cervical cancer still presents a significant health challenge on a worldwide scale. Our objective was to ascertain the potential link between precancerous cervical conditions and levels of acute-phase reactants in the blood serum....
CAR T-cell therapy as a part of adoptive cell therapy (ACT), has become one of the most rapidly growing and promising fields in the Immuno-oncology. As compared to the conventional cancer therapies, CAR T-cell therapy is the single-dose solution for the treatment of various cancers, signi...
As the indications for cancer immunotherapy expand, the recognition of potential irAEs is essential in order to accurately diagnose and manage patients. The clinical presentation is heterogenous, but there are several distinct clinical patterns of neurologic irAEs that are becoming more evident with tim...
Therapeutics - Immunotherapy, Biologics, Vaccines: Biological response modifiers, used to treat cancer, exert their antitumour effects by improving host defense mechanisms against the tumour. They have a direct antiproliferative effect on tumour cells an