Immunologically-cold tumors including glioblastoma (GBM) are refractory to checkpoint blockade therapy, largely due to extensive infiltration of immunosuppressive macrophages (Mϕs). Consistent with a pro-tumor role of IL-6 in alternative Mϕs polari
FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells Glioblastoma is an aggressive type of cancer with poor patient prognosis. Here, the authors show that T cells armed with an FGL2-specific scFV can induce antitumour responses ...
Gliomas are the most prevalent primary malignant brain tumors worldwide, with glioblastoma (GBM) being the most common and aggressive type. De
胶质母细胞瘤(glioblastoma,GBM)是最严重、最恶性的胶质瘤,被诊断GBM的患者中位生存期<2年,并且由于血脑屏障的存在导致药物难以抵送至脑部从而影响药物抗GBM的作用。因此探索新的措施及机制来治疗GBM是十分重要的。GBM具有复杂的TME,其TME中存在大量的免疫细胞群,然而这些免疫细胞群往往受到GBM的影响处于免疫抑制状态。
4 Methods behind oncolytic virus-based DC vaccines in cancer: Toward a multiphase combined treatment strategy for Glioblastoma (GBM) patients. 癌症中基于溶瘤病毒的 DC 疫苗背后的方法 : 针对胶质母细胞瘤 ( GBM ) 患者的多相联合治疗策略。 影响指数 : 1.829 发表时间:2024 来源期刊:Methods Cell Bio...
Healthcare analytics, AI solutions for biological big data, providing an AI platform for the biotech, life sciences, medical and pharmaceutical industries, as well as for related technological approaches, i.e., curation and text analysis with machine learning and other activities related to AI ...
Adoptive cell therapies for glioblastoma. Front Oncol. 2013;3:275. Bregy A, Wong TM, Shah AH, et al. Active immunotherapy using dendritic cells in the treatment of glioblastoma multiforme. Cancer Treat Rev. 2013;39(8):891-907. Cannon MJ, O'Brien TJ. Cellular immunotherapy for ovarian ...
Effective drug delivery and prevention of postoperative recurrence are significant challenges for current glioblastoma (GBM) treatment. Poor drug delivery is mainly due to the presence of the blood-brain barrier (BBB), and postoperative recurrence is primarily due to the resistance of GBM cells to ch...
Hideho Okada, MD, PhD, director, Brain Tumor Immunotherapy Center, professor of Neurological Surgery, University of California, San Francisco, discusses a study exploring vaccination in patients with glioblastoma.Recent Videos Related Content Advertisement Precision Medicine for Prostate Cancer: The ...
Mayra Shanley, PhD, discussed background and future directions for evaluating IL-21 natural killer cells for the treatment of glioblastoma. Read More Strategies for Neoadjuvant NSCLC Treatment Nichole Tucker;Benny Weskler, MBA, MD, FACS, FACCP September 1st 2023 Podcast In season 4, episode 13...