Drug repurposing has emerged as an attractive time- and cost-effective solution. It may also represent a promising strategy to combat drug resistance. The use of immune checkpoint inhibitors for cancer immunotherapy has achieved enormous clinical success. However, only a subset of cancer patients ...
Sipuleucel-T is approved by the FDA as an immunotherapeutic agent for the treatment of patients with asymptomatic or minimally symptomatic castration-resistant prostate cancer (CRPC). Although this approval has raised cost-versus-benefit issues, it has provided proof of concept for the therapeutic ...
The HPV-encoded early proteins, the E6 and E7 oncoproteins, form ideal targets for therapeutic HPV vaccines, since they are consistently expressed in HPV-associated cervical cancer and its precursor lesions and thus play crucial roles in the generation and maintenance of HPV-associated disease. Our...
Immunotherapy, as a powerful strategy for cancer treatment, has achieved tremendous efficacy in clinical trials. Despite these advancements, there is much to do in terms of enhancing therapeutic benefits and decreasing the side effects of cancer immunotherapy. Advanced nanobiomaterials, including liposomes,...
5.1. Target antigens for CAR-NK cells Unlike CAR-T cells, CAR-NK cells can mediate cytotoxic activity against cancer cells in both CAR-dependent and CAR-independent manner. Therefore, a CAR can be developed to induce a moderate activating signal, for example, a CAR without co-stimulatory dom...
A subset of cancer patients undergoing immunotherapy have displayed robust and long-lasting therapeutic responses. Currently, the spotlight is on the use of blocking antibodies against the T-cell checkpoint molecules, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) and programed cell death-1 (...
Other types of cancer immunotherapies include: Adoptive cell therapy Monoclonal antibodies Vaccines Immunotherapy for mesothelioma can be a powerful tool for patients whose cancer has spread to other areas of the body or can’t be surgically removed. Not everyone is a candidate for immunotherapy, but...
Lung cancer is the primary cause of mortality in the United States and around the globe. Therapeutic options for lung cancer treatment include surgery, radiation therapy, chemotherapy, and targeted drug therapy. Medical management is often associated with the development of treatment resistance leading ...
The advent of immunotherapy has made an indelible mark on the field of cancer therapy, especially the application of immune checkpoint inhibitors in clinical practice. Although immunotherapy has proven its efficacy and safety in some tumors, many patient
Preservation and redirection of HPV16E7-specific T cell receptors for immunotherapy of cervical cancer 热度: Prospects for gene-engineered T cell immunotherapy for solid cancers 热度: CAR-T和CAR-NK作为实体肿瘤的细胞肿瘤免疫治疗CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors...