Specific immunotherapy and turning off the T cell:how does it work[J].Annals of Allergy,Asthma & Immunology,2011,(05):381-392.Ozdemir C, Kucuksezer UC, Akdis M, Akdis CA: Specific immunotherapy and turning off the T cell: how does it work? Ann Allergy Asthma Immunol 2011, 107:381-...
It doesn’t work for everyone.Right now, immunotherapy works for less than half the people who try it. Many people only have a partial response. For cancer treatment, this means your tumor could stop growing or get smaller, but it doesn’t go away. For autoimmune disorders, you may not ...
the Parker Institute of Cancer Immunotherapy and 10x Genomics partnered to bring together a group of T cell immunotherapy researchers and single-cell-technology innovators for a day’s workshop. Participants evaluated the current cutting edge of knowledge, identified areas for focused technology developme...
and (iii) antibodies that target two immune-related molecules.117Because the BiTE molecule usually targets one CD3 molecule and one tumor antigen simultaneously, it belongs to the second category of bsAbs (Fig.2b).117BiTEs are the main patterns by which bsAbs work in hematologic malignancies, s...
Cancer vaccines based on messenger RNA have been the subject of recent, in-depth last investigations [2]. Figure6illustrates the process of how mRNA vaccines work to activate the immune system. When the mRNA vaccine is introduced into the body, it is taken up by cells through endocytosis and...
The immune system is made up of a complex network of interconnected mechanisms that work together to provide an adaptive immune reaction against carcinogenesis and infection while maintaining immune tolerance to self-antigens [1]. On a cellular level, cancer is caused due to the accumulation of nu...
It is important to determine the cellular basis for how these agents work in a dynamic and complex TME. An analysis of the TME and its response to these agents is critical to prioritize targets, identify mechanisms of resistance, and design rational treatment combinations. Our experimental design...
Adoptive cell therapy with chimeric antigen receptor (CAR) immunotherapy has made tremendous progress with five CAR T therapies approved by the US Food and Drug Administration for hematological malignancies. However, CAR immunotherapy in solid tumors lag
However, RT doesn’t work the way we want it to, on the contrary, the immunomodulatory effect induced by RT is a double-edged sword that not only enhances systemic antitumor immune response but also promotes immunosuppression to some extent.35,98Generally, IR is deemed to inhibit the immune ...
A. Mechanisms of allergen-specific immunotherapy: multiple suppressor factors at work in immune tolerance to allergens. J. Allergy Clin. Immunol. 133, 621–631 (2014). CAS PubMed Google Scholar Akdis, C. A. & Akdis, M. Mechanisms of allergen-specific immunotherapy and immune tolerance to ...