Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by peripheral immune cell infiltration into the brain and spinal cord, demyelination, glial cell activation, and neuronal damage. Currently there is no cure for MS, however, available disease-modifying...
(1991). Intense immunosup- pression in chronic progressive multiple sclerosis: the Kaiser study. J Neurol Neurosurg Psychiatry, 54: 1054-1060.Likosky WH, Fireman B, Elmore R, et al. Intense immunosuppression in chronic progressive multiple sclerosis: the Kaiser study. J Neurol Neurosurg Psychiatry...
Long-term therapy with glatiramer acetate in multiple sclerosis: effect on T-cells. Glatiramer acetate (GA) is an immunotherapeutic drug for multiple sclerosis (MS). Several mechanisms of action have been demonstrated which target and affe... Ragheb,Samia,Abramczyk,... - 《Multiple Sclerosis》 被...
Multiple sclerosis (MS) is the most common disabling neurological disease of young adulthood. Following advances in the understanding of the immunological mechanisms that underlie the pathogenesis of MS, a growing arsenal of immunomodulatory agents is available. Two classes of immunomodulators are approved...
In MS: Immunosuppression is passé Staley A.Brod, inMultiple Sclerosis and Related Disorders, 2020 Abstract Importance Prolonged and significant alterations of the immune system byimmunosuppressionmakesmultiple sclerosis(MS) patients susceptible toopportunistic infectionsandmalignanciesover long periods of treatme...
Multiple sclerosis. Myasthenia gravis. Pernicious anemia. Reactive arthritis. Rheumatoid arthritis. Sjögren syndrome. Systemic lupus erythematosus. Type I diabetes. Who has the strongest immune system? As such,ostricheshave survived and evolved with one of the strongest immune systems in the animal ki...
The recent emergence of 'higher efficacy/higher risk' therapies in relapsing remitting multiple sclerosis (RRMS) asks questions of current treatment paradigms in this disorder. For those patients who present with very aggressive relapsing disease or early treatment failure on an interferon, a number of...
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system characterized by perivascular inflammation and demyelination and loss of neurologic function. In this disease and its experimental model (experimental autoimmune encephalomyelitis, EAE), axonal and neuronal loss...
Gastrointestinal tract involvement is almost universal in systemic sclerosis but in most patients is relatively mild with symptoms of gastro-oesophageal dy... Salam Ma 被引量: 0发表: 2013年 Increased incidence of lymphoproliferative disorder after immunosuppression with the monoclonal antibody OKT3 in car...
Women have an increased risk of developing diseases such as rheumatoid arthritis and multiple sclerosis compared with men. The female preponderance is believed to depend in part on the influence of sex hormones on the immune system. The mechanism of estrogen-induced immune suppression both in human...