It has long been suspected that multiple sclerosis (MS) is due to a primary autoimmune response to the CNS, perhaps related to an antecedent viral infection. Independent lines of evidence suggest that T-lymphoc
Although clinical trials in multiple sclerosis are extremely difficult to conduct because of the unpredictable course of the disease and the problem of defining and monitoring disease activity, some controlled and several uncontrolled studies suggest that global immunosuppression may result in a small but...
Intense immuno- suppression in chronic progressive multiple sclerosis: the Kaiser study. Journal of Neurol Neurosurg Psychiatry. 1991;54: 1055-60.Likosky WH, Fireman B, Elmore R, et al. Intense immunosup- pression in chronic progressive multiple sclerosis: the Kaiser study. J Neurol Neurosurg ...
Immunosuppressionis the major individual risk factor facilitating the development of disease from infection, particularly that caused byHIV infection. The spread of HIV to rural areas where VL is endemic, and the spread of VL to suburban areas, has resulted in a progressively increasing overlap betwe...
multiple sclerosis. alopecia areata. What is considered immunosuppressive disease? People are said to be immunosuppressed when they havean immunodeficiency disorder due to medicines that weaken the immune system(such as corticosteroids). Immunosuppression is also a common side effect of chemotherapy given ...
Women have an increased risk of developing diseases such as rheumatoid arthritis and multiple sclerosis compared with men. The female preponderance is believed to depend in part on the influence of sex hormones on the immune system. The mechanism of estrogen-induced immune suppression both in human...
MSCs have been experimentally applied in models of multiple sclerosis, myocardial infarction and stroke, solid organ transplantation, liver cirrhosis and chronic inflammatory bowel diseases151 (for an overview of relevant indications, see Supplementary Table 1). Owing to their distinct immunomo- dulatory...
In the experimental autoimmune encephalomyelitis murine model of multiple sclerosis, MSCs were shown to decrease the clinical signs associated with demyelinization when injected before or at the onset of the disease, demonstrating the therapeutic efficacy of MSCs [34]. This effect was associated with ...
thymic atrophy and multiple secondary bacterial infections.141In commercial whitePekin ducks(mallards), the thymic atrophy was temporary, but the bursal atrophy appeared to be irreversible. Lymphoid depletion occurs not only in the thymus and the bursa but also in the spleen and the harderian gland...
Alemtuzumab in the treatment of multiple sclerosis: Key clinical trial results and considerations for use 2015, Therapeutic Advances in Neurological Disorders Progressive multifocal leukoencephalopathy: Why gray and white matter 2013, Annual Review of Pathology: Mechanisms of Disease Progressive multifocal leuk...