Mechanism of action of immunomodulatory agents in multiple myeloma. Med Oncol. 2010;27(Suppl 1):S7–13. CentralReske T, Fulciniti M, Munshi NC. Mechanism of action of immuno- modulatory agents in multiple myeloma. Med Oncol. 2010;27(Suppl 1): S7-S13....
Immunomodulatory agents (IMiD's) have become an important drug category in the treatment of multiple myeloma. The agents have a complex mechanism of action that influence the microenvironment in the bone marrow. The microenvironment is an essential promotor of disease progression and therefore important...
Immunomodulatory agents which include thalidomide and its analogue lenalidomide have recently emerged as an effective treatment option for patients with multiple myeloma. The anti-tumor property of these molecules is probably related to action on tumor microenvironment, anti-angioenesis and several other hi...
Define Immunomodulatory. Immunomodulatory synonyms, Immunomodulatory pronunciation, Immunomodulatory translation, English dictionary definition of Immunomodulatory. n a substance that affects the functioning of the immune system Collins English Dictionar
Phase II Trial of Syncopated Thalidomide, Lenalidomide, and Weekly Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Over the past decade, the novel agents thalidomide, lenalidomide, and bortezomib have emerged as effective treatment in patients with multiple myeloma (MM)... M Tufail,DS...
Inhibitors of CTLA4, PD1 or PDL1 administered as single agents have resulted in durable tumour regression in some patients, and combinations of PD1 and CTLA4 inhibitors may enhance antitumour benefit. Numerous additional immunomodulatory pathways as well as inhibitory factors expressed or secreted by ...
Mitsiades N, Mitsiades CS, Richardson PG, Poulaki V, Tai YT, Chauhan Det al. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications.Blood2003;101: 2377–2380. ...
Cancer MedicineByun JM, Shin DY, Hong J, et al. Distinct predictive impact of FISH abnormality in proteasome inhibitors and immunomo- dulatory agents response: redefining high-risk multiple myeloma in Asian patients. Cancer Med 2018;7:831-41....
喜欢 0 阅读量: 7 摘要: The article presents s on immunomodulatory agents, including synthesis and immunosupressive activity of artemisinin derivatives and preparation of 2-(phenylamino)-pyrimidin-5 amides as cannabinoid 2 receptors modulators to treat immune or inflammatory disorders. 年份: 2007 ...
Similarly, current immunomodulatory drugs (e.g. levamisole and bacterial derivatives) are relatively crude agents with poorly characterised modes of action and poor clinical efficacies.There are some exceptions amongst the current broad-spectrum approach to immunomodulation, including hyposensitization therapy...