organization of these books actively involves studetns in the learning process and reinforces concepts. At the end of each chapter there is a test including multiple choice questions, true/false questions and short answer questions, and every answer involves an explanation. Each book contains icons...
In this section, we answer two puzzling questions. First, how are cDC1 and cDC2 different? IRF4 and IRF8, the factors typically used to distinguish cDC1 and cDC2, are very similar, and little evidence indicates that they bind distinct DNA sequences or interact with different partners. Second...
All authors should agree to be accountable for all aspects of the work to ensure that the questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Changes to authorship The editors of this journal generally will not consi...
In the current study, we sought to investigate the following questions in murine models: (1) the susceptibility of DCs to MVA infection; (2) the phenotypic and functional alteration of DCs upon MVA infection; (3) whether DCs activate T cells via direct or cross-presentation, and (4) whethe...
This review set out to answer several questions related to tumour immunology and the gut. It is evident that in patients with gastrointestinal cancer there is a general depression of the immune response and this seems to be correlated with the stage of the disease. Paradoxically a specific ...
By using this approach, known as meta-analysis, they were able to “...ask questions that are too big for any one study to answer” and “...see if things are consistent over the gamut of labs, methods and people.” (American Psychological Association, online.) Several clear patterns ...
may have serious implications for the effectiveness of the immunity induced by the vaccine. As I predicted in mycoverageof that paper, Australian researchers have since addressed the questions of how frequent these Prn-negative strains are and how recently they’ve arisen. In this post I will tr...
The paper provides an overview of the range of statistical methods that can be used to answer different immunological study questions. We discuss specific aspects of immunological studies and give examples of typical scientific questions related to immunological data. We review classical bivariate and mu...
performed experiments that were not included in the manuscript to generate preliminary data but helped answer some reviewer questions. H.N. and D.N.C. provided bone marrow from the CCR7–GFP mice that they generated. T.L. provided bone marrow from Ikbkb-knockout mice and provided feedback ...
L. et al. Unanswered questions following reports of secondary malignancies after CAR-T cell therapy. Nat. Med. 30, 338–341 (2024). Article CAS PubMed Google Scholar Eyquem, J. et al. Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection. Nature 543, 113–117 ...