Aims Pulmonary large cell neuroendocrine carcinoma (LCNEC) is underdiagnosed on biopsy specimens. We evaluated if routine neuroendocrine immunohistochemical (IHC) stains are helpful in the diagnosis of LCNEC on biopsy specimens. Methods and results Using the Dutch pathology registry (PALGA), surgically ...
diagnosis (MESH)biopsy (MESH)sensitivity and specificity (MESH)WHO classificationLCNECAims Pulmonary large cell neuroendocrine carcinoma (LCNEC) is underdiagnosed on biopsy specimens. We evaluated if routine neuroendocrine immunohistochemical (IHC) stains are helpful in the diagnosis of LCNEC on biopsy ...
The great majority of fungi are easily identified by hematoxylin-eosin staining alone or in combination with special stains such as Gomori methenamine silver stain and Schiff periodic acid stain which are used in routine histopathology [204,205]. However, the morphological diagnosis of deep mycoses, ...
Morphologic differentiation of clear cell hepatocellular carcinoma (HCC-CC) from clear cell renal carcinoma (RCC-CC) may not be possible without the aid of immunohistochemical stains. We performed a battery of immunohistochemical stains on 10 previously diagnosed HCC-CCs, and 10 RCC-CCs, in order ...
In view of this, various immunohistochemical (IHC) stains have been employed to address the subjectivity of morphological assessments [15,16,17,18]. In the case of the INT type AoV cancer, there is often expression of cytokeratin 20 (CK20), whereas the PB type typically exhibits cytokeratin ...
There are currently no diagnostic immunohistochemical stains available. The broad range of myxoid neoplasms in the differential diagnosis includes a variety of sarcomas. Given the notable differences in disease biology among myxoid neoplasms, which range from benign to aggressive, an accurate diagnosis is...
Histopathologic diagnosis of PFMs on sun-damaged skin is also difficult owing to the presence of atypical melanocytic proliferations both in normal-looking sun-exposed skin and in benign PFMs. Immunohistochemical stains are often useful to render a correct diagnosis. The most frequently used markers ...
It has been proposed that care should be exercised in diagnosis because of the variation shown by G-NECs in both histological morphology and immunohistochemical expression. However, no reports have investigated the relationship between the expression pattern at the primary site and that at the ...
INSM1 is more sensitive and interpretable than conventional immunohistochemical stains used to diagnose merkel cell carcinoma. Am J Surg Pathol. 2018. Rush PS, Rosenbaum JN, Roy M, et al. Insulinoma-associated 1: a novel nuclear marker in Merkel cell carcinoma (cutaneous neuroendocrine carcinoma)....
Immunostains show 3 þ positivity for OCT3/4 (c), SOX2 (d) and CD30 (e), supporting the diagnosis of embryonal carcinoma. adopt distinct cell states in response to specific factors. On the basis of these facts, it appears that embryonal carcinoma cells are more similar to somewhat more...