The various antibodies produced by plasma cells are classified by isotype, each of which differs in function and antigen responses primarily due to structure variability. Five major antibody classes have been identified in placental mammals:IgA,IgD,I...
1.Any of a group of large glycoproteins, including all the antibodies that function in the vertebrate immune system, that have a structure consisting of two heavy chains and two light chains. There are five major classes of immunoglobulin isotypes: IgA, IgD, IgE, IgG, and IgM. ...
The NKdim subset exhibits primarily a cytotoxic effector function, whereas NKbright cells can produce immunoregulatory cytokines such as IFN-γ, tumor necrosis factor β (TNF β), IL-10, IL-13, and GM-CSF.40,41 Surprisingly, IVIg-DCs stimulated immunophenotypic changes in NK cells resulting ...
Much of the knowledge of antibody function and structure has been obtained from studies of the homogeneous proteins produced by patients with neoplasms of plasma cells and lymphocytes. There is now little doubt that most of the homogeneous proteins in these patients are structurally normal antibodies ...
In one embodiment, the antibody or immunoglobulin can be recombinantly produced, e.g., produced by phage display or by combinatorial methods. Phage display and combinatorial methods for generating antibodies are known in the art (as described in, e.g., Ladner et al., U.S. Pat. No. 5,22...
Both IL-12 and IL-23 are mainly produced by macrophages and dendritic cells (DCs) and exert relevant roles in mounting innate and adaptive responses [121]. The cytotoxic activity of natural killer cells is enhanced in response to IL-12, which dramatically increases the production of interferon-...
are used for mapping of the epitopes on an antigen. Thus there is also provided an anti-NOGO antibody which binds to the human NOGO-A between amino acids 586 to 685 or 686 to 785 and neutralises the activity of NOGO-A. Such an antibody may be produced according to the methods set ...
Shear Separation is a method of separating macromolecules suspended in a fluid by inducing hydrodynamic forces that depend on size. The forces are produced... MF Hurwitz,JD Brantley - 《Dairy Science & Technology》 被引量: 13发表: 2000年 加载更多来源...
Shear Separation is a method of separating macromolecules suspended in a fluid by inducing hydrodynamic forces that depend on size. The forces are produced... MF Hurwitz,JD Brantley - 《Dairy Science & Technology》 被引量: 13发表: 2000年 加载更多来源...
These types of natural immunoglobulins, however, are not produced only by B-1 cells in the abdominal cavity and do not remain confined to the abdominal cavity. Rather, they can migrate to the spleen as their Mac-1 phenotypes are diminished and produce natural IgM at this site. Moreover, ...