Ig superfamily cell adhesion molecules (IgCAMs) comprise one of the largest gene families in the genome of various animal species. Characteristics Structures The Ig-like domain is composed of 70–110 amino acid residues and has a globular structure containing two β-sheets, each of which consists...
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The immunoglobulin (Ig)-like domain is a typical feature of proteins belonging to the immunoglobulin superfamily The immunoglobulin (Ig)-like domain is aprotein domainthat is similar inamino acid sequenceand structure to the Ig domains of immunoglobulins (Edelman, 1987; Williams & Barclay, 1988)....
Here, we describe the successful de novo design of an immunoglobulin-like domain with high stability and accuracy, which had not been achieved yet and was confirmed by crystal structures. This success became possible by elucidating the requirements for effective formation of cross-β motifs, which ...
SLAMF9 is the most recently identified member of the Slam-family. Like nearly all other Slamf-receptors, it has an extracellular amino-terminal variable immunoglobuline-like domain, a membrane proximal constant immunoglobuline-like domain, a transmembrane region, but no known signaling motifs in its...
Immunoglobulin (Ig) superfamily Cellsurfaceproteins of theIg superfamilyare characterized by the presence of a variable number of related 70–110 amino acid Ig-like domains originally described in the Ig variable and constant regions. SeveralIgSFmembers have been implicated incell adhesion.CD2has been ...
ILT2 is an immune regulatory receptor that contains an extracellular Ig-like domain, is responsible for ligand binding at the cell surface, and has a long cytoplasmic tail containing immunoreceptor tyrosine inhibitory motif (ITIM), which recruits inhibitory phosphatases and mediates inhibition of cell ...
Home > Section > Chapter Teichmann, S.A.; Chothia, C. Journal of Molecular Biology 296(5): 1367-1383 2000 ISSN/ISBN:0022-2836 10698639 10.1006/jmbi.1999.3497 003469218 Article emailed within 0-6 h Buy Now for$19.90 Payments are secure & encrypted ...
Immunoglobulin superfamily expression in primary retinoblastoma and retinoblastoma cell lines. Retinoblastoma (Rb) is the most common intraocular tumor of childhood. In this study we examined primary Rb specimens and Rb cell lines for the expression ... MC Madigan,PL Penfold,NJC King,... - 《...
It was shown that the domain — named M5 — belongs to the newly defined intermediate (I) frame of the immunoglobulin superfamily [14]. From sequence analysis it was also predicted that all the Ig-like modules in titin would adopt the I frame fold because they all share the key residues ...