CELL deathFEATURE selectionImmunogenic cell death (ICD) serves a critical role in regulating cell death adequate to activate an adaptive immune response, and it is associated with various inflammation-related diseases. However, the specific role of ICD-related genes in COVID...
Alzheimer's disease (AD) is the leading cause of dementia worldwide, with recent studies highlighting the potential role of immunogenic cell death (ICD) in the pathogenesis of this neurodegenerative disorder. A total of 52 healthy controls and 64 patient
Immunogenic cell deathRisk modelMYD88Pancreatic cancer (PC) is a malignancy of the gastrointestinal tract that is characterized by a poor prognosis. This study investigates the roles of immunogenic cell death (ICD) genes in the prognosis and progression of PC. Expression data for PC patients were...
Mammalian cells responding to specific perturbations of homeostasis can undergo a regulated variant of cell death that elicits adaptive immune responses. As immunogenic cell death (ICD) can only occur in a precise cellular and organismal context, it shou
Immunogenic cell death (ICD) represents a functionally unique response pattern that comprises the induction of organellar and cellular stress, and culminates with cell death accompanied by the exposure, active secretion, or passive release of numerous DAMPs16,37,39,40,41. The spatiotemporally defined...
A well-known G4 binder acts as a cytostatic modulator of innate immune genes in cancer cells partially related to STING pathway [21]. Our group demonstrates that a novel telomeric G4 ligand effectively triggers immunogenic cell death (ICD) in TNBC [22]. Nevertheless, the immunostimulatory funct...
Immunogenic cell death (ICD) is characterized by the early surface exposure of calreticulin (CRT). As a specific signaling molecule, CRT on the surface of apoptotic tumor cells mediates the recognition and phagocytosis of tumor cells by antigen presenting cells. To date, only a small quantity of...
accumulatingevidencehasdemon- stratedthatimmunogeniccelldeath(ICD)playsakeyroleintheanticancereffectofchemotherapy,radio- therapy,photodynamictherapyandoncolyticvirotherapy.Mostinterestingly,thegutmicrobiotamayimpact theICDprocess.Giventheimportanceofthegutmicrobiotainimmuneresponses,cancerprogressionandthe anticancere...
In recent years a new concept of immunogenic cell death (ICD) has emerged. In this Review, the authors discuss the role of endoplasmic reticulum (ER) stress and reactive oxygen species (ROS) in regulating the immunogenicity of dying cancer cells and how
death. Several infectious pathogens have devised strategies to control cell death and limit the emission of danger signals from dying cells, thereby avoiding immune recognition. Similarly, cancer cells often escape immunosurveillance owing to defects in the molecular machinery that underlies the release ...