Colony formation assayDAMPsImmunogenic cell deathMurine tumor modelTumor vaccinationImmunogenic cell death (ICD) is a form of regulated cell death that is capable of eliciting an immune response. In cancer, tumor cells undergoing ICD are known to emit damage associated molecular patterns (DAMPs) that...
Immunogenic cell death (ICD) is a phenomenon caused by exposing cancer cells to specific stimuli such as immunochemotherapy or immunoradiotherapy (Galluzzi, Buque, Kepp, Zitvogel, & Kroemer, 2017; Gomes-da-Silva et al., 2018; Kepp, Loos, Liu, & Kroemer, 2017; Pitt, Kroemer, & Zitvogel, ...
Immunogenic cell death (ICD) and tumour-infiltrating T lymphocytes are severely weakened by elevated reactive oxygen species (ROS) in the tumour microenvironment. It is therefore of critical importance to modulate the level of extracellular ROS for the reversal of immunosuppressive environment. Here, we...
a mode of drug-induced cell death, known as immunogenic cell death (ICD), can propagate antitumoral immunity to augment therapeutic efficacy. Currently, the molecular hallmark of ICD features the release of damage-associated molecular patterns (DAMPs) by dying cancer cells. Here, we show that ge...
The immunogenic demise of cancer cells can be induced by various chemotherapeutics, such as anthracyclines and oxaliplatin, and provokes an immune response against tumor-associated antigens. Thus, immunogenic cell death (ICD)-inducing antineoplastic agen
In addition, some chemotherapeutic agents provoke immunogenic cancer cell death (ICD), meaning that they induce tumor cell death in a way that those cells elicit a specific immune response. ICD is characterized by a series of alterations that usually do not occur in the context of apoptosis: (...
Schematic illustration of NIR-II-absorbing diimmonium polymer agent achieves excellent photothermal therapy with induction of tumor immunogenic cell death. a A scheme that illustrates the synthesis of P-IDI via nanoprecipitation. b Tumor immunogenic cell death induced by P-IDI based PTT Full size ima...
After that, the level of HMGB1 or CRT was measured by CLSM assay, and the exposure to CRT was also measured by flow cytometry. Moreover, the secretion of ATP was detected by an enhanced ATP assay kit. After different treatments, the luminescence of the cell's supernatant was detected by ...
Define immunogenic. immunogenic synonyms, immunogenic pronunciation, immunogenic translation, English dictionary definition of immunogenic. adj. Capable of inducing an immune response. im′mu·no·ge·nic′i·ty American Heritage® Dictionary of the En
Immunogenic cell death (ICD) represents a functionally unique response pattern that comprises the induction of organellar and cellular stress, and culminates with cell death accompanied by the exposure, active secretion, or passive release of numerous DAMPs16,37,39,40,41. The spatiotemporally defined...