Immunogenic cell death (ICD) represents a functionally unique response pattern that comprises the induction of organellar and cellular stress, and culminates with cell death accompanied by the exposure, active secretion, or passive release of numerous DAMPs16,37,39,40,41. The spatiotemporally defined...
These findings indicate that combining chrysin and radiation significantly enhances cell death through apoptosis-mediated pathways, compared to monotherapy with either chrysin or radiation. Fig. 2 Determination of Apoptosis by Annexin V/PI double staining assay. (a) Representative dot plot and (b) ...
This result indicates that immunogenic cell death of HeLa cells was induced by the detergent treatment. For SDS and Triton X-100, although the cell death was induced, the calreticulin and HMGB1 translocations were not confirmed. The ICD induced HeLa cells were effectively phagocytosed by ...
To further investigate cell death in PT-112-treated cells, we pretreated LNCap-C4 and DU-145 with the pan-caspase inhibitor, Z-VAD-fmk, and/or the RIPK-dependent necroptosis inhibitor, necrostatin-1. In LNCap-C4, only Z-VAD-fmk caused a significant decrease in cell death following PT-112...
Finally, a loss-of-function assay was conducted to assess the role of MYD88 in PC. Two clusters of PC samples were identified, patients in the ICD-low cluster exhibited a higher degree of immune cell enrichment. The survival time of patients in the low-risk group was longer than that of...
Immunogenic cell death (ICD) is a typical type of regulated cell demise, and ICD inducers stimulate the immune responses against dead-cell antigens and exert specific antitumor effects. G-quadruplex (G4) binders targeting the telomeres lead to DNA damage response (DDR) and the potential of harn...
In addition, some chemotherapeutic agents provoke immunogenic cancer cell death (ICD), meaning that they induce tumor cell death in a way that those cells elicit a specific immune response. ICD is characterized by a series of alterations that usually do not occur in the context of apoptosis: (...
Background: Anti-cancer therapy is more successful when it can also induce an immunogenic form of cancer cell death (ICD). Therefore, when developing new treatment strategies, it is extremely important to choose methods that induce ICD and thereby activate anti-tumor immune response leading to the...
Schematic illustration of NIR-II-absorbing diimmonium polymer agent achieves excellent photothermal therapy with induction of tumor immunogenic cell death. a A scheme that illustrates the synthesis of P-IDI via nanoprecipitation. b Tumor immunogenic cell death induced by P-IDI based PTT Full size ima...
Immunogenic cell death (ICD) converts dying cancer cells into a therapeutic vaccine and stimulates antitumor immune responses. Here we unravel the results of an unbiased screen identifying high-dose (10 µM) crizotinib as an ICD-inducing tyrosine kinase inhibitor that has exceptional antineoplastic...