Myeloid dendritic cellsIBDCrohn’s diseaseUlcerative colitisInflammatory bowel diseaseHumanBreakdown of immunological tolerance toward the commensal microflora in genetically susceptible individuals is believed to be the key event in the pathogenesis of inflammatory bowel disease. Dendritic cells (DC) control ...
Centralcontrolofimmunity:Immunobiologyofdendriticcells 1 HistoryofDCStudy 1868P.LangerhansDCswerefirstidentifiedinepidermis(Langerhanscells)1973RM.SteinmanThepresenceofDCinothertissueswas&ZA.Cohnidentified 1980sK.Inaba MurineDCswereexpandedsuccessfullyinvitro 1990sC.Caux&HumanDCswereexpandedsuccessfullyJ.Banchereauin...
Dendritic cells (DCs) are specialized antigen presenting cells (APC) that are fundamental to initiate both immunity and tolerance. DCs play a 'sentinel' role to protect our body from potential pathogens and induce tolerogenic responses toward harmless antigens. The flexibility of DCs or macrophages ...
A recent workshop on "Dendritic Cells: Biology and Therapeutic Applications," sponsored by the Juan March Foundation, brought together basic and clinical research scientists to discuss the mechanisms underlying the control of immune responses and tolerance by dendritic cells (DCs), as well as recent...
Mesenchymal stem cells inhibit the differentiation of dendritic cells through an interleukin-6-dependent mechanism. Stem Cells 2007; 25: 2025–2032. CAS PubMed Google Scholar Najar M, Rouas R, Raicevic G, Boufker HI, Lewalle P, Meuleman N et al. Mesenchymal stromal cells promote or suppress...
Poor in vitro maturation and pro-inflammatory cytokine response of dendritic cells in children at genetic risk of type 1 diabetes. Scand.I Immunol 2004; 60:647–652. Article CAS Google Scholar Allen JS, Pang K, Skowera A et al. Plasmacytoid dendritic cells are proportionally expanded at ...
SI:immuno of diabetes Edited byDr Julia Kzhyshkowska,Dr Galileo Escobedo,Dr Martin Harmsen October 2017 European Macrophage and Dendritic Cell Society (EMDS) Special Issue: Monocytes, dendritic cells and macrophages - basic research and pathophysiological aspects ...
Understanding the mechanisms governing the type of induced immune response after microbial invasion, could be of crucial importance for the rational design of a bacteria-based vaccine. Targeting a vaccine directly to dendritic cells (DCs... M Rescigno,G Rotta,B Valzasina,... - 《Immunobiology》...
This includes activation of B cells, natural killer cells, and antigen-presenting cells including monocytes, macrophages, and dendritic cells. These effects have led to evaluation of CpG ODN as immune adjuvants in immunization where they have been shown in animal models to enhance the development ...
(MDSCs), play an important role in tumor progression, via down-regulation of antitumor responses. MDSCs represent a heterogeneous group of cells originated from the myeloid lineage that are in the immature state. These cells markedly accumulate under pathologic conditions, such as cancer, infection...