“Serious” adverse pregnancy outcomes occurred at similar rates in Tdap- and Td-vaccinated pregnant women in a randomized prospective trial [35], and in Tdap plus influenza sequentially- or concomitantly-vaccinated pregnant women identified in an other database analysis [45]. There was no causal ...
For those aged 19 to 64 years, a 2-year interval between Td and Tdap is acceptable. A provider should, however, consider the risk:benefit ratio of vaccine intervals; for example, if pertussis is epidemic in a community, then a shorter interval should be considered when t...
routine HCP groups: <2 yr interval (received last Td/TT <2 yrs earlier), aged 65 yrs, or pregnant.We surveyed (paper/electronic) HCP vaccinees to assess time since last Td/TT (2 yr vs <2 yr), age, pregnancy status, and local AEs and subjective fever during the 2 wks after Tdap....
Finally, we excluded all women who received non-Tdap tetanus-containing vaccines during pregnancy (ie, tetanus diphtheria [Td]). We identified vaccinations using electronic medical record and insurance claims data that are captured in the standardized VSD vaccine file. We defined a vaccine ...
Korea Tdap × 1Td every 10 y 50 y+, pregnant women, high-risk groups 65 y + and high-risk groups, 1 dose Unvaccinated high-risk groups Unvaccinated and seronegative Seronegative 30- to 39-y-olds Military recruits; dormitory residents Unvaccinated up to 29 y old New Zealand TD, 45, ...
To be included, pregnant women had to be between 18 and 40-year-old; had an ultrasound at 18-22 weeks gestation showing no fetal structural abnormality, and had an uncomplicated singleton pregnancy at the time of screening; had received one dose of aPgen or Tdapgen or only Td vaccine duri...
1). Each Tdap dose (Boostrix, GSK) contained ≥ 2 IU diphtheria toxoid,≥20 IU tetanus toxoid, 8 µg pertussis toxoid (PT), 8 µg filamentous hemagglutinin (FHA), 2.5 µg pertactin (PRN) and 500 µg Al3+. Each placebo dose contained 150 mM NaCl. Both ...
Fig. 2. Geometric mean concentrations of pertussis antigens after immunization with Tdap of (A) adolescents and (B) adults. 3.3. Persistence of antibody responses in adults Over 98% of adults achieved ≥0.01 IU/ml of diphtheria antitoxin 1 month post-vaccination with Tdap or Td (Table 4)....