Recent research demonstrates that vaccination and infection not only activate immune responses in circulating monocytes and tissue macrophages but also affect immune progenitor cells within the bone marrow environment, conferring lasting protection against heterologous infections. These protective effects are attr...
USA, first performed a comprehensive and unbiased analysis of the human antibody response to the RSV F and G proteins in infants before and after RSV infection. They then characterized the changes in the response over time by analyzing antibodies from children, adolescents, and...
Background: Respiratory syncytial virus (RSV) causes respiratory disease throughout life. Here we report differences in naturally acquired immunity with age and presumed exposure.Green, C. A.Sande, C. J.de Lara, C.Thompson, A. J.Silva-Reyes, L.Napolitano, F.Pierantoni, A.Capone, S.Vitelli...
Immunological reactions that occur in the respiratory tract in response to infectious agents have recently gained distinct attention. Humoral (1–20) and cellular immune reactions (16, 21–34) have been identified in the lungs of a number of animal species and of man. Respiratory tract infections...
(e.g.,macrophages) whose role mainly consist in limiting the viral propagation via modulating cytokine production and, generally 2–3 weeks later after contact with the virus, inducing the adaptive immune response [18]. Thus, a failure of innate immunity may result in an abnormal acquired ...
the fact that mostRSV infectionsinhealthy adultsare relatively mild indicates that previous infection does induce substantial protective immunity. RSV indeed does have many described mechanisms to inhibit or alter host defense (Ascough et al., 2018;Canedo-Marroquín et al., 2017). For example, RSV...
which would further undermine the immune response. General characteristics ofhumoral immunityin the elderly include a longer time to development of peak antibody titers, a lower level of the peak titer, and a more rapid decline after immunization. Clinically, these changes in humoral immunity are ev...
Virus-specific nasal immunoglobulin (Ig) A and serum antibody titers in 67 respiratory syncytial virus (RSV)infected adults were compared with titers in ag... W Edward,AR Falsey - 《Journal of Infectious Diseases》 被引量: 155发表: 2004年 Co-infection subverts mucosal immunity in the upper ...
SARS-CoV-2-specific cellular and humoral immunity after bivalent BA.4/5 COVID-19-vaccination in previously infected and non-infected individuals Prior infection or exposure to SARS-CoV-2 may influence immunogenicity and effectiveness of subsequent vaccination to new strains of virus. Here the autho...
Some viruses, however, do cause overt damage to the host, either in isolated cases or as a reaction that commonly occurs after infection. The outcome is influenced by properties of the infecting virus, the circumstances of infection and several factors controlled by the host. In this Review, ...