TLR4 deficiency or antibody blockade has been shown to be beneficial and can effectively protect animals from sepsis-induced shock and high mortality [34,35]. NI-0101 is the first monoclonal antibody to block TLR4 signaling and prevent cytokine release in healthy volunteers after receiving LPS [36...
Complementary and alternative medicine, including Chinese medicine(CM), has been used to treat acquired immune deficiency syndrome(AIDS) for almost 30 years. We aimed to compare the main differences between AIDS treatment and evaluation strategies between CM and Western Medicine(WM), and analyze ...
As a breakthrough strategy for cancer treatment, immunotherapy mainly consists of immune checkpoint inhibitors (ICIs) and other immunomodulatory drugs that provide a durable protective antitumor response by stimulating the immune system to fight cancer.
Acquired Immune Deficiency Syndrome (AIDS) diagnosis and treatmentdoi:US20050002955 A1A monoclonal antibody specific to Nap was prepared by using a crude membrane fraction from a cell line which has a high affinity to Nef as an antigen. A cDNA clone which encodes Nap was obtained by screening ...
Wang P, Gu Z, Huang X, Liu B, Deng X, Ai H, Wang J, Yin Z, Weng S, Yu X, He J: An immune deficiency homolog from the white shrimp, Litopenaeus vannamei, activates antimicrobial peptide genes. Mol Immunol. 2009, 46: 1897-1904. 10.1016/j.molimm.2009.01.005. Article CAS PubMed...
Thus, the deficiency of type I IFN leads to poor innate immune responses in the host against SARS-CoV-2 infection, eventually leading to severe illness. Therefore, enhancing the host's innate immune response by administering type I IFN could be a key to prevent the host from COVID-19 ...
NS4B expression at 48 hpi.DMDBK cells were transfected with siParkin or siNC for 24 h. Then, the cells were infected with NCP BVDV (MOI = 5). RNA from each group was collected at 48 hpi, qRT-PCR assays were performed to determine the IFN-β expression in the indicated treatment...
Thus, regulating the functions of B cells is of great importance for the treatment of these diseases. Delivery of mRNA to B cells can regulate multiple B cells functions, including the antibody production, cytokine secretion, and T cell activation. Researchers have confirmed that B cells can be...
8a, b, PTENα deficiency markedly increased cell susceptibility to ROS-mediated cell death. Moreover, using a series of cell death inhibitors, we found that the ferroptosis inhibitor ferrostatin-1 (Fer-1) was the only one completely abolishing the cell death induced by H2O2 (Supplementary Fig....
Long-term zinc treatment alters the mechanical properties and metabolism of prostate cancer cells Jiri Navratil Monika Kratochvilova Jaromir Gumulec Cancer Cell International(2024) Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells ...