The X chromosome has the highest density of immune-related genes involved in innate and adaptive immune responses [73]. Various pathways significant to the functioning of the immune system have genes which are located on the X chromosome, have been explained in this section. Natural immunomodulator...
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Although the main function of the immune system is defence against pathogens (e.g., viral and bacterial), immune cells also play a crucial role in other processes, such as homoeostasis and development, potential additional targets of selection. Such functions are orchestrated by highly specialised ...
The authors divided the data of cancer patients into five clusters based on their immune system, generated five virtual patients using the data from each cluster, and built their tumor growth model. In this paper, we will use the data from three different clusters to construct a mathematical ...
Posts about immune system written by Dr. Sudipta Saha, Irina Robu, sjwilliamspa, larryhbern, 2012pharmaceutical, and Demet Sag, Ph.D., CRA, GCP
Harnessing the Immune System to Outsmart Cancer: Cutting-Edge Research and Innovations in Immuno-Oncology (hereafter referred to as symposium) is scheduled for August 2nd at the University of Hong Kong, with an expected attendance...
However, recent researchers suggest that PSGL-1 also functions as a negative regulator of the immune system [21, 22]. Notably, the interaction between PSGL-1 and VISTA has been shown to negatively regulate immune cell functions, particularly T cells [18]. V-domain immunoglobulin T-cell ...
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl Acad. Sci. USA 99, 12293–12297 (2002). Article CAS PubMed PubMed Central Google Scholar Gong, J., Chehrazi-Raffle, A., Reddi, S. & Salgia, R. ...
Gene set enrichment analysis (GSEA) was performed to determine different gene sets related to the immune system that were enriched in IS patients and controls (Supplementary Data 1). The top 5 gene sets of the IS were enriched in complement and coagulation cascades, Fc gamma R-mediated ...
that PARPi-treated tumors display significantly higher percentage of CD8+ cells and programmed death-ligand 1 (PD-L1)-positive cells; moreover, this effect was not observed in an immunodeficient mice model, thus indicating that the antitumor effect of PARPis requires a functional immune system.17...