Immune system, the complex group of defense responses found in humans and other advanced vertebrates that helps repel disease-causing entities. Immunity from disease is conferred by two cooperative defense systems: innate immunity and acquired immunity.
Presently, enhanced pathology of lymphoid organs applies primarily to the latter, although it is feasible that still more lymphoid organs or tissues may be added in the future to the list of required organs in guideline-driven toxicity studies. The semiquantitative, structured histological assessment...
Although our library used circulating immune cells as a source, the immune system traverses a broad repertoire of organs, each of which may be key to understanding the biological role of an interaction. We therefore sought to contextualize the interactions of our network by creating an interactive...
140 biomarkers for the immune system (Supplementary Data1) and 687 biomarkers for BBB (Supplementary Data2). A total of 253 immune system and 130 BBB biomarkers passed the false discovery rate (FDR) correction of 5%. After removal of duplicates,...
ASW parasitised byM. hyperodaeare known to have some but not all internal organs consumed (with only the digestive system and some thoracic tissue remaining), have reduced flight capacity, and are reproductively sterilised soon after oviposition [6,11,12]. Significant changes in ASW expression...
In the body, manganese is stored in several organs and tissues, including the liver, nervous system, bone, pancreas, and kidneys. Notably, excess manganese can be secreted into the bile and excreted through the feces [5]. Although manganese-binding proteins are expressed at relatively high ...
Sections were imaged with an optical microscope (Olympus), and staining intensity was assessed according to the semi-quantitative scoring system in considering the staining intensity and area extent. Two independent pathologists scored the sections (double-blinded). The staining intensity was scored as ...
L Santambrogio - Biomaterials in Regenerative Medicine and the Immune System 被引量: 12发表: 2015年 Biomaterial Approaches for Immunomodulation to Enhance Transplantation Tolerance Inducing donor-specific tolerance to transplanted cells and organs, while preserving immune function as a whole, remains a hig...
Sexual dimorphism in the mammalian immune system is manifested as more frequent and severe infectious diseases in males and, on the other hand, higher rates of autoimmune disease in females, yet insights underlying those differences are still lacking. Here we characterize sex differences in the immun...
To advance our understanding of immunology outside the haematopoietic system, here we systematically investigate the regulation of immune genes in the three major types of structural cells: epithelium, endothelium and fibroblasts. We characterize these cell types across twelve organs in mice, using ...