(2) In vivo human studies on patients with primary diagnosis of schizophrenia (DSM-code: 295.90; ICD-10 code: F20.9), schizophreniform (295.40; F20.81), schizoaffective disorder (295.70; F25.2), brief psychotic disorder (298.8; F23), other psychotic disorder (298.9, F29), major depressive...
and that these potential changes could impact the communication between the immune and central nervous systems during the progression of the disorder. To address this hypothesis, we first confirmed the altered state of the two transcription
We identified 7 significant (p< 5.0 × 10−8) protein quantitative trait loci (pQTL) for 38 proteins (Additional file2: Table S4). Most of the pQTL targets were components of the adaptive immune response, such as the complement system (C4, CFB), chemokines (CCL15, CCL25), and...
Therefore, what is urgently needed are novel mechanistic insights into the molecular paths underlying the negative and cognitive symptomatology subtypes of the disorder. Although schizophrenia has been classically observed as a brain disease, current evidence points towards a multi-system network underlying...
Figure 3. Survival rates among patients with positive RIRD (Rheumatological immune-related disorder) status compared to asymptomatic patients. HR = Hazard Ratio, CI = Confidence Interval. Cox Regression adjusted to age, ethnicity, sex, and comorbidities. Table 3. Clinical and sociodemographic charac...