一、皮肤免疫背景介绍 二、银屑病相关机制及热点研究目标 在银屑病中,角质层(表皮的最外层)的细胞堆积异常,导致鳞片的形成,表皮的颗粒层明显减少。表皮网相当拉长,真皮中的血管增大。虽然正常皮肤中含有显著…
Psoriasis is not contagious or life threatening but the sad fact is, it is a chronic genetic disease that still has no known cure. The condition causes the skin to become inflamed, producing red, thickened areas, with a flaky white buildup. It is generally found on the knees, elbows, ...
Psoriasis is a common inflammatory skin disease characterized by infiltration of inflammatory cells into the epidermis and altered keratinocyte differentiation. Psoriasis is currently thought of as a T-cell mediated ‘Type-1’ autoimmune disease. Gene ex
rheumatoid arthritis (RA), multiple sclerosis (MS), and psoriasis [7,8,9]. Notably, the risk of an autoimmune disorder is higher in individuals with PTSD, compared to individuals with other psychiatric disorders [8]. Even though the direction of the association between PTSD and autoimmune disea...
Link between the HPA axis, autonomic nervous system, and inflammation in PTSD The neuroendocrine stress response is comprised of the autonomic nervous system (ANS) and the hypothalamic–pituitary–adrenal (HPA) axis, which relay signals to the peripheral organs and the immune system (Fig.2). Upon...
The functioning of the human immune system is highly dependent on the sex of the individual, which comes by virtue of sex chromosomes and hormonal differences. Epigenetic mechanisms such as X chromosome inactivation, mosaicism, skewing, and dimorphism in
Journal of Investigative Dermatology - The Role of Immune System in the Pathogenesis of Psoriasis 喜欢 0 阅读量: 46 作者:O Baadsgaard,G Fisher,JJ Voorhees,KD Cooper 摘要: Psoriatic involved skin contains an increased number of activated T cells. The mechanism through which these T cells ...
Skin Immune Systems and Inflammation: Protector of the Skin or Promoter of Aging? The immune system may either have a protective role against sunburn and skin cancer or, conversely, promote solar damage. The skin is poised to react to in... MF Bennett,MK Robinson,ED Baron,... - 《Journal...
More than 130 million people around the globe suffer from psoriasis vulgaris, a chronic condition characterized by skin inflammation, scales, and dry patches. However, its pathology is not fully clear. In a recent study, dermatology researchers at Fujita
Millions of people suffer from psoriasis, a chronic, autoimmune disorder that causes scaly patches on the skin and often precedes psoriatic arthritis. While no cure exists, treatments range from topical creams to injected medications that block inflammat