One of the most fascinating things about the human body is the immune system, as it features cells in the human body which work day and night together to protect it from a constant threat — pathogens that are always trying to bring mayhem and chaos. The skin is the first external line ...
Many plant-associated microbes are pathogens that impair plant growth and reproduction. Plants respond to infection using a two-branched innate immune system. The first branch recognizes and responds to molecules common to many classes of microbes, including non-pathogens. The second responds to pathog...
This paper deals with further developments of the kinetic modelling of the cellular dynamics of tumors interacting with an active immune defence system in the presence of cytokine signals. The contents is developed in the framework of the so-called cellular kinetic theory which leads to a modelling...
The immune system is the body’s defence mechanism against pathogens. This system comprises of many cells that work together to protect the body from foreign...
The immune system is a complex and highly cooperative system of cells, tissues, and organs whose primary function is to protect an organism from infection by foreign organisms and from newly arising neoplasms. From: Progress in Molecular Biology and Translational Science, 2012 ...
immune system at the cell-type level. In recent years, the Human Cell Atlas (HCA) has created comprehensive transcriptome reference maps of healthy human organs and tissues at different developmental and adult stages, with the ultimate objective of characterising every cell type in the human body...
Whereas the resident innate immune system patrols the CNS as a first line of defence, the presence of the adaptive immune response is controlled by a series of interfaces that include the brain-blood-barrier and the choroid plexus that likely represent a protective measure against immune-mediated ...
Here, we provide an overview of the latest discoveries in this field and discuss how they impact our understanding of the ubiquitin system in host defence mechanisms as well as self-tolerance. Keywords autoimmunity; DUBs; E3 ligases; inflammation; LUBAC DOI 10.1002/embr.201338025 | Received 24 ...
Recognition of endogenous nucleic acids by the innate immune system. Immunity 44, 739–754 (2016). Article CAS PubMed Google Scholar Chen, Q., Sun, L. & Chen, Z. J. Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing. Nat. Immunol. 17, 1142–1149 (2016). ...
the function of these proteins is to evade/disrupt the host immune system and ensure viral persistence10. From the perspective of the virus, these actions are critically important because viruses depend on living cells for replication. This review focuses on current knowledge regarding two factors. ...