The article discusses the result of a study which describes the role of the intraflagellar transport (IFT) in immune synapse formation. RNA interference in T cells was performed and showed that IFT knockdown impairs clustering of T cell receptor (TCR)-CD3 complexes at the immune synapse. The ...
The discovery of phosphatase micro-exclusion from signaling elements in immunological synapses and innate phagocytic synapses define a common functional unit at a common sub-micron scale across synapse types. Bundling of information from multiple antigen receptor microclusters by an immunological synapse ...
typically mediated by the T-cell antigen receptor (TCR) on CTLs or by activating NK receptors on NK cells, mobilizes these granules, which move toward the immune synapse (IS) and fuse with the synaptic membrane, releasing their contents into the intercellular space...
ting via the endothelium and infiltrating through the surrounding stromal tissue [17]. Lastly, the TCRs on the surface of infiltrating CD8+T‐cells need to establish contact with the peptide MHC-I complexes on the surface of APCs to release perforin and lytic granules in the immune synapse, t...
B-cell activation and immune synapse (IS) formation with membrane-bound antigens are actin-dependent processes that scale positively with the strength of antigen-induced signals. Importantly, ligating the B-cell integrin, LFA-1, with ICAM-1 promotes IS formation when antigen is limiting. Whether ...
Synapse. 2009b;63(7):565–73. doi:10.1002/syn.20637. PubMed Central CAS PubMed Google Scholar Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. 2009c;65(9):732–41. doi:10.1016/j....
T Lymphocyte recognition of antigens leads to the formation of a highly organized structure termed immune synapse (IS) by analogy with the neuronals synapse. Sorting nexin 27 (SNX27) controls the endosomal traffic of PSD95, Dlg1, ZO-1 (PDZ) domain-interacting proteins, and its alteration is...
IS Immune synapsePSTPIP1 is a cytosolic adaptor protein involved with T-cell activation, differentiation, and migration. Upon cognate T-cell contact, PSTPIP1 is recruited to surface-expressed CD2, where it regulates f-actin remodeling. An immune synapse (IS) is thereby rapidly formed, consisting...
(LCMV) infection model, TIM3 expression promoted short-lived effector T cell development, accompanied with enhanced AKT/mTOR signaling.89Another work showed that TIM3 interacted with multiple proximal TCR signaling molecules in the immune synapse, with TIM3 blockade enhancing stable synapse formation ...
We also pay attention to the related receptor assemblies and possibilities of chemically synthesized carbon nanotubes to simulate functions of the natural ones. 关键词: Chemical synapse, nanotube. DOI: 10.2174/092986708783497265 被引量: 49 年份: 2008 ...