For SARS-CoV-2, the causative agent of covid-19, the focus is mainly on IgM, IgG, and IgA antibodies that can neutralise the virus by binding to the spike and other membrane proteins and thus preventing infection.1 Understanding the lesser known roles of T cells and cellular immunity will...
we and others have applied the single-cell RNA sequencing (scRNA-seq) to profile the immune cell heterogeneity and dynamics in BALFs, blood, and respiratory tract samples from the COVID-19 patients. Collectively, those studies revealed a stunted IFN response, depletion...
World-leading influenza immunology researcher and laboratory head at the Doherty Institute, Katherine Kedzierska said that because the team were able to dissect the immune response leading to successful recovery from COVID-19, they might also help to find an effective vaccine. "This is an incredib...
We partnered with Dr. Paula Kavathas of the Yale University School of Medicine, to learn more about how viruses infect people, how the body responds to them, and impact of vaccines on diseases. In our continuing series on COVID-19(Coronavirus), we partne
Examining the genomes of patients who have a severe response to COVID-19 will help identify crucial immune-related variants (see 'Investigations into host response to COVID-19'). However, asymptomatic people, the ideal control group for comparison, are extremely difficult to find. Until testing ...
‘The population diversity of HLA molecules, as well as the specificity of their work do not let the virus avoid the T-cell immune response. But the virus has managed to hide its S-protein from one of the HLA molecules. Importantly, most of COVID-19 vaccines (Sputn...
Medications commonly used are impacting our immune response to infections like COVID-19. Some common drugs can help and others hinder immune responses. The largest clinical review of immune responses to paracetamol, non-steroidal anti-inflammatory drugs (NSAIDs), and opioid analgesics, with a foc...
Immune responses to SARS-CoV-2 in children of parents with symptomatic COVID-19Compared to adults, children with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have predominantly mild or asymptomatic infections, but the underlying immunological differences remain unclear. Here, we ...
We identified six hallmarks that collectively define the major immunological abnormalities in COVID-19. The first hallmark, occurring early after the infection, is the dysregulated type I IFN response, which blunts the establishment of an efficacious rapid antiviral response. The inability to restrict ...
People possess psychological processes that help them avoid pathogens, which is particularly important when novel infectious diseases (e.g., COVID-19) spread through the population. Across two studies we examined whether trait pathogen avoidance (operationalized as perceived vulnerability to disease; PVD...