For SARS-CoV-2, the causative agent of covid-19, the focus is mainly on IgM, IgG, and IgA antibodies that can neutralise the virus by binding to the spike and other membrane proteins and thus preventing infection.1 Understanding the lesser known roles of T cells and cellular immunity will...
But COVID-19, which targets surface cells throughout the respiratory system including in the lungs, has an average incubation of six days and a much slower disease progression. Mathematical modeling suggests that the adaptive immune response may kick in before the target cells are depleted, slowing...
we and others have applied the single-cell RNA sequencing (scRNA-seq) to profile the immune cell heterogeneity and dynamics in BALFs, blood, and respiratory tract samples from the COVID-19 patients. Collectively, those studies revealed a stunted IFN response, depletion...
The coronavirus disease 2019 (COVID‐19) pandemic has created unprecedented challenges worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes COVID‐19 and has a complex interaction wi
New research has found that previous infection, whether it was symptomatic or asymptomatic, does not necessarily protect you long-term from COVID-19, particularly against new Variants of Concern.
Examining the genomes of patients who have a severe response to COVID-19 will help identify crucial immune-related variants (see 'Investigations into host response to COVID-19'). However, asymptomatic people, the ideal control group for comparison, are extremely difficult to find. Until testing ...
How do we study the immune response? The serum of COVID-19 infected individuals was of interest as it is the part of our blood that contains crucial information about our immune system. Analysis of the serum made it possible to create a detailed timeline of the level of ‘neutralizing antib...
Pfizer–BioNTech COVID-19 vaccine is the well-known form of the vaccine. Nucleic acids such as DNA and RNA vaccines are manufactured utilising the genetic material from SARS-Cov2 to Immune response to SARS-COV-2 The immune system is a complex system of cellular components, tissues and organs...
Immune Response to Third and Fourth COVID-19 Vaccination in Hemodialysis Patients and Kidney Transplant Recipients. Viruses. 2022; 14(12):2646. https://doi.org/10.3390/v14122646 Chicago/Turabian Style Affeldt, Patrick, Felix Carlo Koehler, Karl August Brensing, Martin Gies, Eva Platen, ...
Researchers may have come one step closer toward understanding how the immune system contributes to severe COVID-19. In a study published in Science Immunology, researchers at Karolinska Institutet in Sweden show that so-called natural killer (NK) cells