Torrisi, et al., An immune stratification reveals a subset of PD-1/LAG-3 double-positive triple-ne- gative breast cancers, Breast Cancer Res. BioMed... G Bottai,C Raschioni,A Losurdo,... - 《Breast Cancer Research》 被引量: 21发表: 2016年 The genomic landscape of breast cancer and...
Methods . From the gene expression profiles of 137 IBC and 252 non-IBC clinical samples, we measured the fractions of 22 immune cell types, expression of signatures associated with tertiary lymphoid structures (TLS) and with the response to ICIs (T cell-inflamed signature: TIS) and of 18 ...
The immune landscape of breast cancers is dynamic and heterogeneous, with significant variation observed across patients, subtypes and disease settings (early breast cancer v. metastatic). Using data on more than 10,000 samples across 33 different tumors available in The Cancer Genome Atlas database...
The Cancer Genome Atlas (TCGA) has profoundly illuminated the genomic landscape of human malignancy. Genomic and transcriptomic data derived from bulk tumor samples have been used to study the tumor microenvironment (TME), and measures of immune infiltration define molecular subtypes of ovarian, melanom...
Studies have characterized the immune escape landscape across primary tumors. However, whether late-stage metastatic tumors present differences in genetic immune escape (GIE) prevalence and dynamics remains unclear. We performed a pan-cancer characteriza
The genomic landscape of breast cancer and its interaction with host immunity Breast, 29 (2016), pp. 241-250 View PDFView articleView in ScopusGoogle Scholar [125] S. Loi, et al. RAS/MAPK activation is associated with reduced tumor-infiltrating lymphocytes in triple-negative breast cancer: th...
with other genetic alterations known to drive the disease. When the team analyzed the tumors from these mice, they saw profound differences in the types and relative numbers of the immune cells that had accumulated in and around the tumor, what they call the tumors' "immune landscape". ...
The single-cell pathology landscape of breast cancer. Nature. 2020;578(7796):615–20. Article CAS PubMed Google Scholar Risom T, Glass DR, Averbukh I, Liu CC, Baranski A, Kagel A, McCaffrey EF, Greenwald NF, Rivero-Gutiérrez B, Strand SH, et al. Transition to invasive breast cancer...
Cancer immunotherapy has revolutionized cancer treatment, and it relies heavily on the comprehensive understanding of the immune landscape of the tumor microenvironment (TME). Here, we obtain a detailed immune cell atlas of esophageal squamous cell carcinoma (ESCC) at single-cell resolution. Exhausted ...
In comparison to well-characterized syngeneic models of epithelial cancers, this study identifies key features of the immune landscape that are unique to sarcoma models. For example, TAMs are the predominant myeloid cell population in our UPS and RMS syngeneic tumors, whereas MDSCs are the most pr...