with elevated liver enzymes being one of the signs of subclinical HCMV infection [186]. On the other hand, HCMV-induced hepatitis with elevated liver enzymes is the most common characteristic of liver infection among immunocompromised individuals...
In conclusion, oral microbes maintain a delicate balance during health but this balance might be compromised with immunosuppression leading to conditions (like dental caries) that could manifest in the oral cavity. There is evidence of dysbiosis of the oral microbiota in immunocompromised children. Howe...
restoring a healthy immune system, and eliminating residual tumor cells from the host [17]. However, the success of Allo-HSCT is often compromised by GVHD, wherein
Pulmonary tuberculosis The lungs are the most commonly affected organ in an immunocompetent host during TB infection. Lung involvement in subjects having active TB has been estimated at 79–87%, whilst the estimate of lung involvement is similar in immunocompromised hosts, like those having HIV–HIV...
The majority of these infections contributing to increased morbidity and mortality in healthy and immunocompromised patients respectively. It is a well-known fact that immune compromised patients, premature infants, cancer patients are more prone to fungal infections than immune competent individuals [1]....
years, have demonstrated that intradermal influenza vaccines are able to confer a better immune response than TIVs at a full antigen dosage in the elderly and an equivalent response, at a lower antigen dose, in healthy adults and in patients with severe chronic diseases or immunocompromised [66]...
Immunocompromised mice [athymic nude mouse (nu/nu)] and subsequently the severe combined immunodeficient (SCID) mice have provided the opportunity to screen anticancer drugs in human tumor xenografts in mice for decades (175). Due to the compromised immune function of the mice, these analyses have...
People who are immune-compromised [109]. 4. Numerous factors can make a person immunocompromised, including cancer treatment, smoking, bone marrow or organ transplants, immune deficiencies, poorly controlled HIV or AIDS, and prolonged use of corticosteroids and other immune-suppressing drugs. [110]...
vary as a function of time post-engraftment6,24,25,26. A delay of human immune cell development in humanized mice is logical if one considers that in normal mice, immune system development beginsin utero27. The humanized mouse model requires that an immune compromised host receive injections ...
(>500 cells/mm3vs. <200 cells/mm3) were associated with a reduced risk of breakthrough infection. An important observation in this study was that an additional (third) vaccine dose decreased risk of breakthrough infections in PWH. In a large study of immunocompromised patients, Sun et al. ...