These T3 cells become "traitors" to the body by promoting the growth of new blood vessels, which help the tumor survive in areas with low oxygen and limited nutrients. Depleting T3 cells or weakening their ability to function can inhibit tumor growth, according to the study. "This discovery ...
Metabolism of immune cells in cancer. Nature Reviews Cancer(IF72.5)Pub Date : 2020-07-06, DOI:10.1038/s41568-020-0273-y Robert D Leone1, Jonathan D Powell1 Affiliation Through the successes of checkpoint blockade and adoptive cellular therapy, immunotherapy has become an established treatment mod...
Through the successes of checkpoint blockade and adoptive cellular therapy, immunotherapy has become an established treatment modality for cancer. Cellular metabolism has emerged as a critical determinant of the viability and function of both cancer cells and immune cells. In order to sustain prodigious...
The article focuses on a study by Carola Ries, scientist at the research lab Roche in Penzberg, Germany, and colleagues related to the role of antibodies in regulation of tumor associated macrophages, which appeared in a 2014 issue of the periodical "Cancer Cell."...
Immunotherapy strategies, such as novel immune checkpoint inhibitors, STING/CD40 agonists, macrophage-based surface backpack anchoring, ex vivo polarization approaches, DC-based tumor vaccines, and CAR-engineered innate immune cells, aim to enhance their anti-tumor potentia...
Monocytes: A New Player in Cancer Immunity The team first analyzed the tumor environment in both models by profiling gene expression at the level of single cells, and then sorted and quantified immune cell types based on specific markers on their surface. “We were very interested when ...
Asst Prof Jeyasekharan commented, “Previously, studying immune cells in cancer was conducted in 'bulk', providing only a general overview of their presence in tumours. However, with technological advances now available, our team could examine the molecular features of macrophages with single-cell...
The study found that theimmune cellsin breast tissue of healthy women carrying BRCA1 or BRCA2 gene mutations show signs of malfunction known as exhaustion. This suggests that the immune cells can't clear out damaged breast cells, which can eventually develop into breast cancer. ...
Recent studies have demonstrated the potential of natural killer (NK) cells in immunotherapy to treat multiple types of cancer. NK cells are innate lymphoid cells that play essential roles in tumor surveillance and control that efficiently kill the tumor
Cancer cells as well as surrounding stromal and inflammatory cells engage in well-orchestrated reciprocal interactions to form an inflammatory tumor microenvironment (TME). Cells within the TME are highly plastic, continuously changing their phenotypic and functional characteristics. Here we review the ...