NHS: N-hydroxysuccinimide; NMP: N-methylpyrrolidinone; PABC: p-aminobenzyl-carbamoyl; PAB-OH: p-aminobenzyl alcohol; Phe:L-phenylalanine; PNP: p-nitrophenol; PNPCF: p-nitrophenylchloroformate TFA: trifluoroacetic acid; THF: tetrahydrofuran; Trp: L-tryptophan; Val: L-valine; Z: benzyloxycarbonyl...
In the absence of 1-propanethiol, newly generated AQMs could undergo addition reactions with existing nucleophilic substrates including 4-aminobenzyl alcohol derivatives (adduct of AQMs with water molecules) and aniline residues at depolymerizing chain termini. Note that the latter case will deaccelerate ...
Here we present a "click to self‐immolation" strategy based on aroyl azide‐capped SIP precursors, enabling the facile construction of diverse SIPs with different trigger units through a Curtius rearrangement and alcohol/thiol‐isocyanate "click" reaction. This strategy is also app...