A dose-titration study indicated that an optimal dose in regards to worm kill, target animal safety, and practicality of use was 2.5 mg/kg, given twice 24 hours apart. An alternate regime to treat severe heartworm disease (class 3) has been quite successful (2.5 mg/kg onceDM Keister...
The signs exhibited by these dogs, in addition to the signs described above, included collapse, severe salivation, vomiting, respiratory distress, cyanosis, stupor, and death within 4 hours of the first dose in two dogs and within 20 hours of the second dose in one dog....