The present disclosure relates to an oral, immediate release, abuse deterrent liquid filled capsule containing polyethylene glycol and at least one active pharmaceutical ingredient
and a paddle speed of 50 rpm were used up to 20 h for sustained-release metoprolol succinate layer. During the test, the medium temperature was maintained at 37 ± 0.5 °C. Sample aliquots (10 mL) were withdrawn at several proper time intervals (e.g., 30 min for immediate-release amlod...
The immediate-release formulation were tested for disintegration. Apparatus A for normal size tablets and capsules was used according to pharmacopoeial methods [34]. The disintegration test was conducted at 37 ˝C, for a single dosage unit placed in each of the 6 tubes of the basket (six ...