Cellular immediate-early genes (IEGs) share a close structural homology with some viral oncogenes. In the eukaryotic genome these counterparts of oncogenes have been termed proto-oncogenes. Recent advances in cellular biology have identified the activation and deactivation of IEGs as molecular ...
即刻早期基因（Immediate early genes ， IEGs）在受到各种各样的细胞刺激时，它们会短暂而迅速地被激活。它们代表了一种长期的反应机制，在任何新的蛋白质合成之前，在对刺激的第一轮反应中，在转录水平上被激活。因此，IEGs不同于“晚期反应”基因，后者只有在早期反应基因产物合成后才会被激活。因此，...
immediate early genes原理 它们的激活通常不依赖于新的蛋白质合成。IEGs 的表达能够快速响应各种外界信号。这些基因在神经生物学中具有重要作用。可以参与神经元的可塑性和记忆形成过程。IEGs 的调控机制复杂多样。包括转录因子的结合以及染色质的修饰。它们能快速改变细胞的生理状态。部分 IEGs 编码转录因子,进一步调控...
This book provides a compilation of the most up-to-date literature on the topic of immediate early genes (IEGs). It reviews and details experiments and theories that challenge the reader to expand their view on how IEG research is currently being used to advance our understanding of static an...
Sas-Chen A, Avraham R, Yarden Y. A crossroad of microRNAs and immediate early genes (IEGs) encoding oncogenic transcription factors in breast cancer. J Mammary Gland Biol Neoplasia 2012;17:3-14.A. Sas-Chen, R. Avraham, Y. Yarden, A crossroad of microRNAs and immediate early genes (I...
The protein products of immediate early genes (IEGs) behave as transcriptional regulators and play an important role in the regulation of gene expression associated with liver cell proliferation and apoptosis. The aim of this study was to examine whether the transcription of IEGs was induced by ob...
in the presence of inhibitors of DNA replication, i.e. early and immediately-early genes, mapping to similar regions in theviral genomeand yielding translation products of similar size distribution (Salas et al., 1986), suggesting that ASFV initiates earlygene transcriptionimmediately upon infection....
The expression of immediate early genes (IEGs), particularlyc-Fos, ArcandZif268has been used as a marker of neural activity in a vast number of spatial memory studies. For over two decades, most of the experiments relied on immunohistochemical detection in the fixed tissue, harvested 90–120 ...
Immediate-early genes (IEGs) can be activated and transcribed within minutes after stimulation, without the need forde novoprotein synthesis, and they are stimulated in response to both cell-extrinsic and cell-intrinsic signals. Extracellular signals are transduced from the cell surface, through recepto...
IEGs: Immediate early genes Jun: Jun gene JUN: Jun protein Krox: Krox gene KROX: Krox protein Krox-24: Krox-24 gene LD: Laterodorsal thalamic nucleus LTP: Long term potentiation MAPK: Mitogen-activated protein kinases MB: Mammillary bodies MEC: Medial entorhinal cortex MECS:...