if side effects are dose limiting, the lower dose of 4 mg may be used [seeClinical Studies]. For the treatment of cluster headache, the efficacy of lower doses has not been established.
The efficacy of IMITREX nasal spray was unaffected by presence of aura; duration of headache prior to treatment; gender, age, or weight of the subject; or concomitant use of common migraine prophylactic drugs (e.g., beta-blockers, calcium channel blockers, tricyclic antidepressants). There ...