例如,亚胺培南/西司他丁 (Imipenem/Cilastatin)是一种经典的碳青霉烯复方制剂,主要用于治疗严重感染。对于复杂耐药菌引起的感染,亚胺培南/西司他丁/瑞来巴坦 (Imipenem/Cilastatin/Relebactam)展现了更强的疗效,而帕尼培南/倍他米隆 (Panipenem/Betamipron)则针对重症感染具有显著作用。美罗培南/法硼巴坦 (Meropenem/Va...
Cilastatin could limit the metabolism of imipenem in the kidneys, while relebactam could prevent enzymolysis of the active imipenem [35]. In contrast to some other β-lactamase inhibitors, relebactam can reform its ring system for rebinding to target enzymes after de-acylation from the active ...
However, owing to their instability toward renal dehydropeptidase-I (DHP-I) and theirrenal toxicity,imipenemhad to be co-administrated withcilastatin, a DHP-I inhibitor, and panipenem with betamipron, a renal protective agent. Anotherweaknessof these antibiotics is their short half-life, which ...
Common Generic Name(s): imipenem/cilastatin/relebactam, imipenem/cilastatin Na/relebactam, imipenem/cilastatin sodium/relebactam Pronunciation: i-mi-PEN-em, REL-e-BAK-tam, sye-la-STAT-in Drug Classes: carbapenem antibiotic, dehydropeptidase inhibitor, beta-lactamase inhibitor Availability: prescription ...
The dosage of imipenem/cilastatin should be reduced in patients with renal impairment. This is a preview of subscription content, log in via an institution to check access. Similar content being viewed by others Imipenem/Cilastatin/Relebactam: A Review in Gram-Negative Bacterial Infections Article...
Imipenem was first approved by the FDA in November 1985 as the combination product Primaxin marketed by Merck & Co.Imipenem is indicated, in combination with cilastatin with or without relebactam, for the treatment of bacterial infections including respiratory, skin, bone, gynecologic, urinary tract...
(imipenem 300 mg, cilastatin 300 mg, and relebactam 150 mg) Every 6 hours 15 to 29 0.5 grams (imipenem 200 mg, cilastatin 200 mg, and relebactam 100 mg) Every 6 hours End Stage Renal Disease (ESRD) on Hemodialysisc 0.5 grams (imipenem 200 mg, cilastatin 200 mg, and relebactam 100 ...
百度试题 题目CRE所致肾盂肾炎首选药物为 A.Ceftazidime-avibactamB.Meropenem-vaborbactamC.Imipenem-cilastatin-relebactamD.CefiderocolE.以上均正确相关知识点: 试题来源: 解析 E 反馈 收藏
To preserve newly developed antimicrobials such as ceftazidime–avibactam, meropenem–vaborbac- tam, imipenem–cilastatin–relebactam, and cefiderocol and to efficiently allocate limited healthcare and public health resources for infection control, it is recommended that CRE is defined solely using the ...
Tazobactam/ceftolozane (TAZ/CTLZ) and relebactam/imipenem/cilastatin (REL/IPM/CS) are expected to be effective for treating patients with antimicrobial-resistant infections, particularly gram-negative pathogens, but nationwide surveillance of these has not been investigated thoroughly in Japan. Pseudomonas...