Imipenem is a carbapenem antibiotic with a broader antimicrobial spectrum and greater potency than other beta-lactam antibiotics. It typically used in combination with cilastatin, an agent that reduces the metabolism of imipenem by inhibiting a dehydropeptidase present in the kidney tubules. Cilastatin ...
Pure tone audiograms were performed before and after dosing in 11 of 12 subjects; no changes were noted. We conclude that the combination of imipenem and cilastatin was well tolerated and safe. Clinical Pharmacology and Therapeutics (1985) 37, 539–543; doi: 10.1038/clpt.1985.85...
Imipenem + Cilastatine inj. brhrbrImipenem + Cilastatine 500 MG + 500 MG Powder for injection Specifications Selling Points International Approvals/Standards; Place of Origin; Price; Quality Service Model Vial Supplied from France Measured In ...
Imipenem/cilastatin is effective for the treatment of a wide variety of infections including those due to multiresistant organisms. Alone, or in combination with an aminoglycoside, imipenem is used to treat serious mixed infections including urinary tract and lower respiratory infections, intraabdominal ...
in combination with cilastatin with or without relebactam, for the treatment of bacterial infections including respiratory, skin, bone, gynecologic, urinary tract, and intra-abdominal as well as septicemia and endocarditis.Imipenem is a beta-lactam antibiotic belongings to the subgroup of carbapenems. ...
Imipenem undergoes enzymatic inactivation in the kidneys. In order to avoid this problem, it is used in a 1:1 ratio in combination with cilastatin—the sodium salt of [R-[R,S-(Z)]]-7-[(2- amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)aminocarbonyl-2-heptenoic acid (32.1...
Imipenem is a chemically stable thienamycin derivative with an antibacterial activity that is broader in spectrum and of greater potency than most of the third generation cephalosporins. Combination with cilastatin, an inhibitor of renal brush-border dehydropeptidase-I, increases both urinary and plasma...
Imipenem/cilastatin. A reappraisal of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy Emergence of oxacillinase-mediated resistance to imipenem in Klebsiella pneumoniae. Imipenem-EDTA disk method for differentiation of metallo-beta-lactamase-producing clinical isolates of Pseudomonas...
Cilastatin sodium (MK-0791) is an inhibitor of this enzyme. The combination of MK-0787/MK-0791 was administered by intravenous drip infusion in a dose of 500mg/500mg once or twice a day for 3 to 9 days to patients with surgical infections. These included 4 patients with septicemia, 5 ...
RECARBRIO™ (imipenem, cilastatin, and relebactam) for injection, for intravenous use Initial U.S. Approval: 2019 ---INDICATIONS AND USAGE --- RECARBRIO is a combination of imipenem, a penem antibacterial, cilastatin, a renal dehydropeptidase inhibitor, and relebactam, a beta- lactamase inhibi...