Imine formation under physiological conditions represents a challenging reaction due to the strong propensity of aldimines to be hydrolyzed. Herein we disclose the remarkable effect of supramolecular multivalency on increasing imine stability. A family of reactive aldehydes was synthesized bearing ...
Propose a suitable mechanism to show the imine formation in the given reaction. 5PRACTICE PROBLEM Draw the structure of the imine given below. The (E) isomer of the methyl imine of acetophenone. 1 views 6PRACTICE PROBLEM Propose a suitable mechanism to show the imine formati...
Benzophenone imine is commonly used as a reagent in various chemical reactions, offering a versatile platform for the formation of carbon-nitrogen bonds. It can be used to synthesize a wide range of compounds, including pharmaceuticals, dyes, and polymers. Benzophenone imine is also known for its...
Covalent organic frameworks (COFs) are porous crystalline polymers that result from the formation of covalent bonds between precisely assembled organic units. Linkage chemistry is a crucial factor in the controllable synthesis and resulting physicoc
(2015), ChemInform Abstract: Total Synthesis of Fluoxetine and Duloxetine Through an in situ Imine Formation/Borylation/Transimination and Reduction Approach. ChemInform, 46: no. doi: 10.1002/chin.201503216 Author Information Dep. Chem., Univ. Durham, Durham DH1 3LE, UK Publication History Issue ...
FURTHER EVIDENCE FOR THE DIENONE-IMINE INTERMEDIATE IN THE FISCHER INDOLE SYNTHESIS: AN UNCATALYZED FISCHER REACTION UNDER MILD CONDITIONSEvidence has been presented for the transient formation of a dienone-imine intermediate in the Fischer indole synthesis analogous to the dienone intermediate found in...
Under reactive conditions enamines (N-alkylation) are formed as the main products instead of the usually observed homologous imines (C-alkylation). The influence of the type of imine, solvent and alkylating agent on the mode of alkylation is discussed.G....
(b). The active pocket is displayed in surface representation. The docked1a, cofactor NADP+, and residue 170 (D170 in N559 and Y170 in N559-M6) are shown as sticks. The red dashed line denotes the formation of a hydrogen bond between substrate1aand Y170. The black arrows indicate ...
H. Directed evolution of cytochrome C for carbon–silicon bond formation: bringing silicon to life. Science 354, 1048–1051 (2016). Article CAS PubMed PubMed Central Google Scholar Wijma, H. J. et al. Enantioselective enzymes by computational design and in silico screening. Angew. Chem. ...
Due to the reversibility of the imine formation, complexes with different ligands were obtained depending on the reaction conditions. Three complexes, [Fe(imine3tren)(OAc)2] (1), [Fe(imine3tren)(OAc)]OTf (2) and [(imine3tren)2Fe2(F)2](SbF6)2 (3), could be synthesized and ...