Non-standard amino acidsConformational analysisRamachandran mapDensity Functional Theory (DFT)Replacement of the main chain peptide bond by imidazole ring seems to be a promising tool for the peptide-based drug design, due to the specific prototropic tautomeric as well as amphoteric properties. In ...
Imidazole is a planar 5-membered ring. Imidazole is a highly polar compound. Imidazole has been used extensively as a corrosion inhibitor. Imidazole is incorporated into many important biological molecules. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Imidazole...
Imidazole (1,3-diazole) (1) is a five-membered heterocyclic ring system characterized by the presence of both aza (–N=) and amine (–NH–) nitrogen atoms in the ring [1]. It is an amphoteric compound having both acidic and basic nitrogen atoms. It is soluble in water and most orga...
6.Therefore, it can be concluded that both imidazole ring and thiazole ring have bioactivity. 因而我们可以确信咪唑环和噻唑环是具有生物活性的. 7.Little said people with type 2 diabetes have higher levels of an amino acid byproduct called imidazole propionate in their blood. 8.A new type of ...
BIOLOGICAL ACTIVITY:Imidazole is a planar 5–membered ring. Imidazole is a highly polar compound. Imidazole has been used extensively as a corrosion inhibitor.Imidazole is incorporated into many important biological molecules. The most pervasive is the amino acid histidine, which has an imidazole side...
Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents. Health Hazard ...
R5 is hydrogen or lower alkyl; R6 is hydrogen, lower alkyl, lower alkylthio or a residue of the formula -NR7R8; and R7 and R8 each is lower alkyl or taken together with the nitrogen atom are a 5- or 6-membered saturated heterocycle; and pharmaceutically acceptable acid addition salts th...
用途:Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar.[1] The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.[3] ...
(1,2,4-triazolyl) can together with the carbon to which they attached form a carbonyl group; R4 is aryl, substituted alkyl or aryloxy, or when R2 and R3 form an oxygen containing ring, can be hydrogen or unsubstituted alkyl; and n is 0, 1 or 2; together with acid addition salts, ...
10.1 ppm and a methylene proton signal adjacent to the imidazole ring at ca. 2.6 ppm obviously split into two peaks in the 1H NMR spectrum of PImPh0 (Figure 2, up). Namely, the formation of two types of 6-membered intramolecular hydro- gen bonding is possible between an amino proton ...