the new class of drugs called tricyclic imidazolderivate formula what a of r and r3 inferior alkyl and the other hydrogen or less alkyl, r2 inferior alkyl, n is the number 0 or 1, a is a residue of formula r4, r5, r6 and r7 and r8 is hydrogen or alkyl, the inferior inferior ...
and D. Stevens. “39 – Drugs Active against Fungi, Pneumocystis, and Microsporidia.” Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases 23 1 (2015): 479-494.Imidazole synthesis Synthesis of Imidazole from N-BOC-IMIDAZOLE...
A recently discovered and structurally distinct class of antiepileptic drugs is the (arylalkyl)imidazoles. Two independently discovered representatives of this class, denzimol (alpha-[4-(2-phenylethyl)phenyl]-1H-imidazole-1-ethanol) and nafimidone (2-(1H-imidazol-1-yl)-1-(2-naphthalenyl)ethanone...
The objective compounds (I) or their salts having superior antimycotic activity are useful as drugs for human and animal use. For example, the minimum inhibitory concentrations (MIC) of 1-[1-[2-(4-chloro-α-methylbenzyloxy)phenyl]vinyl]imidazole.oxalate in in vitro antimicrobial tests were foun...
The modulatory sites on the GABAAreceptor complex, such as for example the benzodiazepine binding site, are the targets for anxiolytic drugs, such as the classical anxiolytic benzodiazepines. However, they are associated with a number of undesirable features. ...
synergist of boric acid agents, preparation of pesticides and fungicides; in addition, it is also used as urea formaldehyde resin curing agent, photographic drugs, adhesives, coatings, rubber curing agents, anti rash agents, etc It is the raw material of electrostatic agent and organic synthesis ...
[15]containing in heterocyclic bioactive compounds are the main source of the reactivity of the target skeleton, the activity of the compounds, and interactions between target drugs.Triazoles(pyrrodiazoles) are a versatile class of heterocycle compounds. Many applications indrug discoverytarget triazole...
It is also utilized as a starting material for the preparation of pharmaceutical intermediates and active pharmaceutical ingredients. Additionally, 1H-Imidazole-4-carbonitrile exhibits excellent stability and compatibility with other reagents, making it a valuable tool in the development of novel drugs and...
However, when combined with chemotherapeutic drugs (antineoplastic) the antitumor effect observed is higher than the sum of effects of each agent alone. As used herein, the terms “catalytic pocket”, “catalytic site”, “active site” collectively and indistinctly refer to a region of the ...
Further information on the use of prodrugs may be found in Pro-drugs as Novel Delivery Systems, Vol. 14, ACS Symposium Series (T. Higuchi and W. Stella) and Bioreversible Carriers in Drug Design, Pergamon Press, 1987 (Ed. E. B. Roche, American Pharmaceutical Association). Prodrugs in ...